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AuthorMuñoz Balbontín, Yolanda
AuthorStewart, Derek
AuthorShetty, Ashalatha
AuthorFitton, Catherine A
AuthorMcLay, James S
Available date2019-05-15T07:43:36Z
Publication Date2019-05-01
Publication NameObstetrics and Gynecologyen_US
Identifierhttp://dx.doi.org/10.1097/AOG.0000000000003217
CitationBalbontín, Yolanda Muñoz .Herbal Medicinal Product Use During Pregnancy and the Postnatal Period: A Systematic Review. Obstetrics & Gynecology. 133(5):920–932
ISSN0029-7844
URIhttp://hdl.handle.net/10576/11558
AbstractTo report the incidence and nature of herbal medicinal products' adverse events and herb-drug interactions used by some pregnant and postnatal women. The Allied and Complementary Medicine Database, the Cumulative Index to Nursing and Allied Health Literature, EMBASE, the Cochrane Library, MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov were searched from inception until August 2018. Any studies reporting adverse events, herb-drug interactions or absence thereof associated with herbal medicinal products used during pregnancy or the postnatal period were included. Conference abstracts, pilot studies, and nonhuman studies were excluded. All included studies were critically appraised by two independent reviewers. Database searches retrieved 3,487 citations. After duplicate removal and review of titles, abstracts, and full-text, 115 articles were critically appraised. After excluding irrelevant and low-quality articles, 74 articles were included for data extraction and synthesis. Adverse drug reactions, congenital malformations, fetal growth retardation or herb-drug interactions were the primary study objective reported by 19 of the 74 included studies, 16 cohort studies, one cross-sectional survey, and two randomized controlled trials. A total of 47 herbal medicinal products and 1,067,071 women were included in this review. Use of almond oil was associated with preterm birth (odds ratio 2.09, 95% CI 1.07-4.08), oral raspberry leaf was associated with cesarean delivery (adjusted odds ratio [AOR] 3.47, 95% CI 1.45-8.28); heavy licorice use was associated with early preterm birth by 3.07-fold (95% CI 1.17-8.05). African herbal medicine mwanaphepo was associated with maternal morbidity (AOR 1.28; 95% CI 1.09-1.50), and neonatal death or morbidity. Fourteen studies reported absence of adverse events. Four studies reported herb-drug interactions, but none studied adverse events arising from them. The use of herbal medicinal products during pregnancy and the postnatal period should be discouraged until robust evidence of safety is available. PROSPERO, CRD42017081058.
Languageen
PublisherLippincott, Williams & Wilkins
Subjectherbal medicines
Subjectadverse events
Subjectinterations
Subjectpregnancy
Subjectlactation
Subjectsystematic review
TitleHerbal Medicinal Product Use During Pregnancy and the Postnatal Period: A Systematic Review.
TypeArticle Review
Pagination920 - 932
Issue Number5
Volume Number133
dc.identifier.essn 1873-233X


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