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AuthorBenameur, Tarek
AuthorOsman, Aisha
AuthorParray, Aijaz
AuthorAit Hssain, Ali
AuthorMunusamy, Shankar
AuthorAgouni, Abdelali
Available date2019-05-28T06:25:32Z
Publication Date2019
Publication NameOxidative Medicine and Cellular Longevityen_US
Identifierhttp://dx.doi.org/10.1155/2019/6475187
CitationTarek Benameur, Aisha Osman, Aijaz Parray, Ali Ait Hssain, Shankar Munusamy, and Abdelali Agouni, “Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes,” Oxidative Medicine and Cellular Longevity, vol. 2019, Article ID 6475187, 23 pages, 2019. https://doi.org/10.1155/2019/6475187.
ISSN1942-0900
IdentifierArticle ID 6475187
URIhttp://hdl.handle.net/10576/11618
AbstractMicroparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific to cells they originate from. Virtually, all cells can shed MPs, and therefore, they can be found in all body fluids, but also entrapped in tissues. Of interest and because of their easy detection using a variety of techniques, circulating MPs were recognized as biomarkers for cell activation. MPs were also found to mediate critical actions in intercellular communication and transmitting biological messages by acting as paracrine vehicles. High plasma numbers of MPs were reported in many cardiovascular and metabolic disturbances that are closely associated with insulin resistance and low-grade inflammation and have been linked to adverse actions on cardiovascular function. This review highlights the involvement of MPs in cardiovascular complications associated with diabetes and discusses the molecular mechanisms that underpin the pathophysiological role of MPs in the onset and progression of cellular injury in diabetes.
SponsorNPRP award (NPRP8-1750-3-360) from Qatar National Research Fund (a member of Qatar Foundation) and a Qatar University high collaborative grant (QUCG-CPH-2018\2019-2)
Languageen
PublisherHindawi
Subjectmicroparticles
Subjectdiabetes
Subjectcardiovascular complications
TitleMolecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes.
TypeArticle
Pagination23
Volume Number2019
ESSN1942-0994


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