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المؤلفAgouni, Abdelali
المؤلفParray, Aijaz S
المؤلفAkhtar, Naveed
المؤلفMir, Fayaz A
المؤلفBourke, Paula J
المؤلفJoseph, Sujata
المؤلفMorgan, Deborah M
المؤلفSantos, Mark D
المؤلفWadiwala, Muhammad F
المؤلفKamran, Saadat
المؤلفSivaraman, Siveen K
المؤلفShuaib, Ashfaq
تاريخ الإتاحة2019-05-30T08:53:39Z
تاريخ النشر2019-03-19
اسم المنشورFrontiers in Neurology
المعرّفhttp://dx.doi.org/10.3389/fneur.2019.00251
الاقتباسAgouni A, Parray AS, Akhtar N, Mir FA, Bourke PJ, Joseph S, Morgan DM, Santos MD, Wadiwala MF, Kamran S, Sivaraman SK and Shuaib A (2019) There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia. Front. Neurol. 10:251. doi: 10.3389/fneur.2019.00251
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11620
الملخصStroke attacks were found to be present at a younger age in patients from Southeast Asia (SE) and the Middle East (ME) resident in the state of Qatar. Extracellular vesicles (EVs), which are small membrane vesicles with pro-thrombotic properties, may contribute to the high risk of stroke in this population. Thus, total and cell-specific medium size EVs were counted by flow cytometry in platelet-free plasma from healthy volunteers and patients with transient ischemic attacks (TIA) and acute ischemic stroke (AIS) from SE and ME. Acutely, within 48 h of attacks, there was an increase in total endothelial EVs in TIA (6.73 ± 1.77; = 0.0156; = 21) and AIS (11.23 ± 1.95; = 0.0007; = 66) patients compared to controls (2.04 ± 0.78; = 24). Similar increases were also evident in EVs originating from platelets, erythrocytes, granulocytes, and leukocytes. Compared to controls, there was also an increase in EVs derived from activated endothelial cells, platelets, granulocytes, leukocytes, and pro-coagulant EVs (Annexin V) at 5 and 30-days following the acute events, while a decrease was observed in erythrocyte-derived EVs. This is the first study characterizing EVs in TIA and AIS patients from ME and SE showing an increase in EVs associated with endothelial and platelet cell activation, which may contribute to the elevated risk of stroke at a younger age in this population.
راعي المشروعQatar University high collaborative grant (QUCG-CPH-2018\2019-2)
اللغةen
الناشرFrontiers Media
الموضوعacute ischemic stroke (AIS)
biomarkers
extracellular vesicles (EVs)
thrombosis
transient ischemic attacks (TIA)
العنوانThere Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia.
النوعArticle
رقم المجلد10
ESSN1664-2295
dc.accessType Open Access


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