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AuthorMaaliki, Dina
AuthorShaito, Abdullah A
AuthorPintus, Gianfranco
AuthorEl-Yazbi, Ahmed
AuthorEid, Ali H
Available date2019-05-30T08:59:54Z
Publication Date2019-05-01
Publication NameCurrent Opinion in Pharmacologyen_US
Identifierhttp://dx.doi.org/10.1016/j.coph.2019.04.014
CitationMaaliki D, Shaito AA, Pintus G, El-Yazbi A, Eid AH. Flavonoids in hypertension: a brief review of the underlying mechanisms. Curr Opin Pharmacol. 2019 May 15;45:57-65. doi: 10.1016/j.coph.2019.04.014.
ISSN1471-4892
URIhttp://hdl.handle.net/10576/11621
AbstractFlavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of many cardiovascular diseases, particularly hypertension. Observational studies suggest inverse associations among either of these three combinations: a) anthocyanin intake and risk of myocardial infarction (MI), b) flavanone intake and risk of ischemic stroke and c) flavonol intake and risk of type 2 diabetes mellitus. Human randomized controlled trials (RCTs) show that catechins and quercetin impart significant blood pressure lowering effects. Mechanistically, flavonoids mediate their antihypertensive effects through increasing nitric oxide (NO) bioavailability, reducing endothelial cell oxidative stress or modulating vascular ion channel activity. In this review, we focus on the six main subgroups of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones. We further discuss their antihypertensive effects, and their possible mechanisms of regulating blood pressure. We conclude by addressing the safety of these compounds as well as their potential use in hypertension management and treatment.
SponsorThis publication was made possible by an MPP fund (#320133) from the American University of Beirut to Ali Ei.
Languageen
PublisherElsevier
SubjectFlavonoids and hypertension
TitleFlavonoids in hypertension: a brief review of the underlying mechanisms.
TypeArticle
Pagination57-65
Volume Number45
dc.identifier.essn 1471-4973


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