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AuthorMarei, Hany E
AuthorAlthani, Asma
AuthorCaceci, Thomas
AuthorArriga, Roberto
AuthorSconocchia, Tommaso
AuthorOttaviani, Alessio
AuthorLanzilli, Giulia
AuthorRoselli, Mario
AuthorCaratelli, Sara
AuthorCenciarelli, Carlo
AuthorSconocchia, Giuseppe
Available date2019-06-13T04:25:29Z
Publication Date2019-06-01
Publication NameBiochemical Pharmacologyen_US
CitationMarei, H. E., Althani, A., Caceci, T., Arriga, R., Sconocchia, T., Ottaviani, A., ... & Sconocchia, G. (2019). Recent perspective on CAR and Fcγ-CR T cell immunotherapy for cancers: Preclinical evidence versus clinical outcomes. Biochemical Pharmacology.‏
AbstractThe chimeric antigen receptor Tcell (CAR-T cell) immunotherapy currently represents a hot research trend and it is expected to revolutionize the field of cancer therapy. Promising outcomes have been achieved using CAR-T cell therapy for haematological malignancies. Despite encouraging results, several challenges still pose eminent hurdles before being fully recognized. Directing CAR-T cells to target a single tumour associated antigen (TAA) as the case in haematological malignancies might be much simpler than targeting the extensive inhibitory microenvironments associated with solid tumours. This review focuses on the basic principles involved in development of CAR-T cells, emphasizing the differences between humoral IgG, T-cell receptors, CAR and Fcγ-CR constructs. It also highlights the complex inhibitory network that is usually associated with solid tumours, and tackles recent advances in the clinical studies that have provided great hope for the future use of CAR-T cell immunotherapy. While current Fcγ-CR T cell immunotherapy is in pre-clinical stage, is expected to provide a sound therapeutic approach to add to existing classical chemo- and radio-therapeutic modalities.
SubjectCAR T cells
SubjectFcγ-CR T cell
SubjectHematological malignancies
SubjectSolid cancers
TitleRecent perspective on CAR and Fcγ-CR T cell immunotherapy for cancers: Preclinical evidence versus clinical outcomes.

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