Biomedical Research Center
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Biomedical Research Center Research [837 items ]
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Environmental Amoxicillin Exposure Induces Cardiotoxicity in Zebrafish Embryos: A Comprehensive Assessment of Heart Function and Molecular Responses
( MDPI , 2025 , Article)Background/Objectives. Environmental pollution poses a significant threat to human health, primarily through the degradation of natural ecosystems. Emerging organic contaminants (EOCs), such as pharmaceuticals like ... -
N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications
( Wiley , 2025 , Article)Aims: N-lactoyl amino acids (Lac-AA) are emerging as crucial players in metabolic research, with potential implications for disease mechanisms and therapeutic interventions. This study exploress the role of Lac-AA in insulin ... -
N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease
( Wiley , 2025 , Article)N-lactoyl amino acids (Lac-AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various ... -
Patients in hospital with confirmed bacterial airway infection are significantly more likely to have a respiratory virus co-infection
( Microbiology Society , 2025 , Article)Introduction. Respiratory viruses are seen as cofactors in bacterial airway infection, often leading to bacterial pneumonia. This study addressed their role in hospitalized patients with bacterial infection confirmed by ... -
Characterization of Flow Structure and Wall Shear Stress in Patient-Specific Abdominal Aortic Aneurysm Phantom Using Particle Image Velocimetry
( American Society of Mechanical Engineers (ASME) , 2025 , Article)Abdominal aortic aneurysm (AAA) is an irreversible dilation of the abdominal aorta that carries a significant risk of rupture if not adequately screened and treated. This condition poses a severe threat, with a mortality ... -
Emerging Insights into Corynebacterium Kroppenstedtii Complex Associated Breast Abscesses: A Retrospective Study
( Taylor and Francis , 2025 , Article)Introduction: Corynebacterium kroppenstedtii complex (CKC), including C. kroppenstedtii, C. parakroppenstedtii, and C. pseudokroppenstedtii, has been implicated in breast abscesses and granulomatous mastitis, presenting ... -
Evaluating indices of insulin resistance and estimating the prevalence of insulin resistance in a large biobank cohort
( Frontiers , 2025 , Article)Introduction: Insulin resistance (IR) is involved in the pathogenesis of various metabolic disorders. Several surrogate indices of IR have been proposed. We assessed the performance of seven clinically relevant indirect ... -
Immune histories and natural infection protection during the omicron era
( Springer Nature , 2025 , Article)Background: Past immunological events can either enhance or compromise an individual's future immune protection. This study investigated how different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural ... -
Intranasal and Pulmonary Lipid Nanoparticles for Gene Delivery: Turning Challenges into Opportunities
( Dove Medical Press Ltd , 2025 , Article Review)Delivery of nano-therapeutics through the nasal route offers a promising approach for several applications, including intranasal conditions, pulmonary delivery, brain targeting, and vaccination. Despite its potential, this ... -
Impact of meteorological factors on transmission of respiratory viruses across all age groups in the hot arid climate in Qatar
( Frontiers Media SA , 2025 , Article)Background: The association between meteorological parameters and viral transmission in temperate and subtropical arid climates is not fully understood. The climate in Qatar reaches extremes of heat and humidity but retains ... -
Insects in agricultural greenhouses: a metagenomic analysis of microbes in Trialeurodes vaporariorum infesting tomato and cucumber crops
( Frontiers Media SA , 2025 , Article)Introduction: With the predicted 9-10 billion world population increase by 2050 and its accompanying need for sustainable food production, and with the harsh climate conditions challenging agriculture and food security in ... -
Machine learning applications in the analysis of sedentary behavior and associated health risks
( Frontiers Media SA , 2025 , Article Review)Background: The rapid advancement of technology has brought numerous benefits to public health but has also contributed to a rise in sedentary lifestyles, linked to various health issues. As prolonged inactivity becomes a ... -
Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood. The Triglyceride-Glucose (TyG) index is an emerging, ... -
Direct medical cost of first-ever acute ischemic stroke in malaysia: a retrospective cohort study
( Nature , 2025 , Article)Understanding the economic impact of first-ever stroke in a multiethnic population like Malaysia is essential for informed resource allocation. This study aimed to evaluate the direct medical costs associated with first-ever ... -
Repurposing Nirmatrelvir for Hepatocellular Carcinoma: Network Pharmacology and Molecular Dynamics Simulations Identify HDAC3 as a Key Molecular Target
( MDPI , 2025 , Article)Background: Hepatocellular carcinoma (HCC) is one of the most common and fatal malignancies worldwide, characterized by remarkable molecular heterogeneity and poor clinical outcomes. Despite advancements in diagnosis and ... -
Phytocompounds as potential inhibitors of p300-HIF1α interaction: A structure-based screening and molecular dynamics simulation analysis
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1) [1]. For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
In vitro and in silico analysis of anticancer activity of terpenoids of Dittrichia viscosa (L.) Greuter essential oil
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)There is a continuous global search for new anticancer agents from natural sources. In this study, the essential oils of Dittrichia viscosa (L.) Greuter leaves (DVEO) were extracted by hydrodistillation and chemically ... -
Antiproliferative activity of sesquiterpene lactones from Dittrichia viscosa (L.) Greuter: In vitro and in silico studies
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Plant-derived metabolites have provided promising leads in the search for safer anticancer chemo-therapies. Among these, sesquiterpene lactones, predominantly present in the genus of the Aster-aceae family, exhibit great ... -
Optimization of ultrasonic-assisted extraction (UAE) of phenolic and antioxidant compounds from Ephedra foeminea Forssk. using response surface methodology (RSM)
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Ephedra foeminea Forssk., a Mediterranean shrub with diverse traditional medicinal applications, is rich in bioactive metabolites [1,2]. This study optimized the ultrasonic-assisted extraction (UAE) of phenolic and ... -
Silicone quaterium-22 surfactant as an eco-friendly carbon steel anticorrosive: Assessment of corrosion inhibition properties and ecotoxicity in zebrafish embryos
( Elsevier , 2025 , Article)Corrosion of carbon steel pipelines in the oil and gas industry presents operational and environmental challenges, requiring safer alternatives to toxic corrosion inhibitors. This study evaluates Silicon-Q-22 (SQ22) as a ...
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