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AuthorAndrews, Sarah F
AuthorChambers, Michael J
AuthorSchramm, Chaim A
AuthorPlyler, Jason
AuthorRaab, Julie E
AuthorKanekiyo, Masaru
AuthorGillespie, Rebecca A
AuthorRansier, Amy
AuthorDarko, Sam
AuthorHu, Jianfei
AuthorChen, Xuejun
AuthorYassine, Hadi M
AuthorBoyington, Jeffrey C
AuthorCrank, Michelle C
AuthorChen, Grace L
AuthorCoates, Emily
AuthorMascola, John R
AuthorDouek, Daniel C
AuthorGraham, Barney S
AuthorLedgerwood, Julie E
AuthorMcDermott, Adrian B
Available date2019-08-21T05:21:26Z
Publication Date2019-07-01
Publication NameImmunity
Identifierhttp://dx.doi.org/10.1016/j.immuni.2019.06.024
CitationAndrews SF, Chambers MJ, Schramm CA, Plyler J, Raab JE, Kanekiyo M, Gillespie RA, Ransier A, Darko S, Hu J, Chen X, Yassine HM, Boyington JC, Crank MC, Chen GL, Coates E, Mascola JR, Douek DC, Graham BS, Ledgerwood JE, McDermott AB. Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. Immunity. 2019 Jul 16. pii: S1074-7613(19)30294-8. doi: 10.1016/j.immuni.2019.06.024.
ISSN1074-7613
URIhttp://hdl.handle.net/10576/11698
AbstractVaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons at the single-cell level of the kinetics, Ig repertoire, and activation phenotype of established pre-existing memory B cells recognizing conserved epitopes and the newly generated memory B cells directed toward H7 strain-specific epitopes. The recall response to conserved epitopes on H7 HA involved a transient expansion of memory B cells with little observed adaptation. However, the B cell response to newly encountered epitopes was phenotypically distinct and generated a sustained memory population that evolved and affinity matured months after vaccination. These findings establish clear differences between newly generated and pre-existing memory B cells, highlighting the challenges in achieving long-lasting, broad protection against an ever-evolving virus.
Languageen
PublisherElsevier
SubjectH7N9
Ig repertoire
Tbet
activated B cells
hemagglutinin
influenza
memory B cells
vaccine response
TitleActivation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.
TypeArticle
Pagination398-410
Issue Number2
Volume Number51
ESSN1097-4180
dc.accessType Abstract Only


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