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المؤلفSohail, Muhammad U
المؤلفYassine, Hadi M
المؤلفSohail, Aaqib
المؤلفAl Thani, Asmaa A
تاريخ الإتاحة2019-09-05T11:22:22Z
تاريخ النشر2019-08-04
اسم المنشورReview of Diabetic Studies
المعرّفhttp://dx.doi.org/10.1900/RDS.2019.15.35
الاقتباسSohail et al "Impact of Physical Exercise on Gut Microbiome, Inflammation, and the Pathobiology of Metabolic Disorders" , Rev Diabet Stud, 2019, 15:35-48
معرّف المصادر الموحدwww.The-RDS.org
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11785
الملخصThe gastrointestinal tract (GIT) harbors a complex and diverse microbial composition that outnumbers our own body cells and their gene contents. These microbes play a significant role in host metabolism and energy homeostasis. Emerging evidence suggests that the GIT microbiome significantly contributes to host health and that impairments in the microbiome may cause the development of metabolic diseases. The microbiome architecture is shaped by several genetic and environmental factors, including nutrition and physical activity. Physical exercise has preventive or therapeutic effects in respiratory, cardiovascular, neuroendocrine, and muscular diseases. Yet, we still have little information of the beneficial effects of physical exercise on GIT health and microbial composition. Furthermore, we are not aware whether exercise-derived benefits on microbiome diversity can beneficially influence other tissues and body organs. The aim of this article is to review the available literature on exercise-induced microbiome changes and to explain how these changes may induce inflammatory, immune, and oxidative responses that may contribute to the improvement of metabolic disorders. A systemic and comprehensive search of the relevant literature using MEDLINE and Google Scholar databases was conducted during fall 2018 and spring 2019. The search identified sixty-two research and review articles that discussed exercise-induced microbiome changes. The review of the relevant literature suggests that exercise-induced microbial changes affect the host's immune pathways and improve energy homeostasis. Microbes release certain neuroendocrine and immune-modulatory factors that may lower inflammatory and oxidative stress and relieve patients suffering from metabolic disorders. Exercise-induced changes in microbial diversity are able to improve tissue metabolism, cardiorespiratory fitness, and insulin resistance.
اللغةen
الناشرThe Society for Biomedical
الموضوعdiabetes
exercise
microbiome
inflammation
immune response
obesity
oxidative stress
العنوانImpact of Physical Exercise on Gut Microbiome, Inflammation, and the Pathobiology of Metabolic Disorders.
النوعArticle Review
الصفحات35-48
رقم المجلد15
dc.accessType Open Access


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