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AuthorIsmail H.M.
AuthorZamani S.
AuthorElrayess M.A.
AuthorKafienah W.
AuthorYounes H.M.
Available date2019-10-17T07:44:37Z
Publication Date2018
Publication NamePolymers
ISSN20734360
URIhttp://dx.doi.org/10.3390/polym10040455
URIhttp://hdl.handle.net/10576/12149
AbstractReactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-co-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications. - 2018 by the authors.
SponsorWe would like to thank Fatima Mraiche for supplying the H9C2 cardiomyoblasts and Nabeel Abdulrahman for his support in the fluorescent imaging. The support of Qatar University Central Lab Unit team led by Saeed Al-Meer is highly appreciated. We acknowledge Michelle Somerville at the University of Bristol for her help with tissue culture studies.
Languageen
PublisherMDPI AG
dc.source Scopus
SubjectBiocompatibility
SubjectCardiac tissue engineering
SubjectParticulate leaching
SubjectPhoto-crosslinking
SubjectPoly(diol-tricarballylate)
SubjectReactive electrospinning
TitleNew three-dimensional poly(decanediol-co-tricarballylate) elastomeric fibrous mesh fabricated by photoreactive electrospinning for cardiac tissue engineering applications
TypeArticle
Issue Number4
Volume Number10


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