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المؤلفYounes, Nadin
المؤلفYounes, Salma
المؤلفAlsharabasi, Ola A
المؤلفEl Zowalaty, Mohamed E
المؤلفMustafa, Ibrahim
المؤلفJahromi, Mohamed
المؤلفUddin, Shahab
المؤلفAl-Nesf, Mariam
المؤلفPintus, Gianfranco
المؤلفZayed, Hatem
تاريخ الإتاحة2019-10-31T08:28:17Z
تاريخ النشر2019-10-01
اسم المنشورCurrent Molecular Medicine
المعرّفhttp://dx.doi.org/10.2174/1566524019666191024104930
الاقتباسYounes, Nadin. et. al. "Immunogenetics of Celiac Disease: A focus on Arab countries" Current Molecular Medicine 2019
معرّف المصادر الموحدhttp://hdl.handle.net/10576/12189
الملخصCeliac Disease (CD) is a complex immunogenic disease mainly triggered by gluten intake in genetically susceptible individuals with a prevalence of 1 in 100-300. CD results from the interplay between genetic and environmental factors. Genetic susceptibility is believed to play a prominent role in the pathogenicity of CD, mainly due to human leukocyte antigen (HLA)-related class II genes. Although CD is well-recognized among Arab populations, there are few studies on the genetic epidemiology and prevalence of CD in the Arab countries. Therefore, in this review, we aim to highlight the importance of studying this disease in the Arab world in the context of a global perspective. Within the few studies published so far, we found that Arab populations have a distinctive susceptibility genetic profile from other ethnic groups with the DQ2.5 and DQ8 genotypes that are considered the major genotypes that confer susceptibility among Arab patients with CD. Our findings will pave the way to perform further epidemiological studies that will help identify potential therapeutic targets against CD among Arab patients that are diagnosed with CD.
اللغةen
الناشرBentham Science Publishers
الموضوعArab countries
Celiac disease
HLA
genetic susceptibility
gluten
incidence
prevalence
العنوانImmunogenetics of Celiac Disease: A focus on Arab countries.
النوعArticle
dc.accessType Abstract Only


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