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AuthorYounes, Nadin
AuthorYounes, Salma
AuthorAlsharabasi, Ola A
AuthorEl Zowalaty, Mohamed E
AuthorMustafa, Ibrahim
AuthorJahromi, Mohamed
AuthorUddin, Shahab
AuthorAl-Nesf, Mariam
AuthorPintus, Gianfranco
AuthorZayed, Hatem
Available date2019-10-31T08:28:17Z
Publication Date2019-10-01
Publication NameCurrent Molecular Medicine
Identifierhttp://dx.doi.org/10.2174/1566524019666191024104930
CitationYounes, Nadin. et. al. "Immunogenetics of Celiac Disease: A focus on Arab countries" Current Molecular Medicine 2019
URIhttp://hdl.handle.net/10576/12189
AbstractCeliac Disease (CD) is a complex immunogenic disease mainly triggered by gluten intake in genetically susceptible individuals with a prevalence of 1 in 100-300. CD results from the interplay between genetic and environmental factors. Genetic susceptibility is believed to play a prominent role in the pathogenicity of CD, mainly due to human leukocyte antigen (HLA)-related class II genes. Although CD is well-recognized among Arab populations, there are few studies on the genetic epidemiology and prevalence of CD in the Arab countries. Therefore, in this review, we aim to highlight the importance of studying this disease in the Arab world in the context of a global perspective. Within the few studies published so far, we found that Arab populations have a distinctive susceptibility genetic profile from other ethnic groups with the DQ2.5 and DQ8 genotypes that are considered the major genotypes that confer susceptibility among Arab patients with CD. Our findings will pave the way to perform further epidemiological studies that will help identify potential therapeutic targets against CD among Arab patients that are diagnosed with CD.
Languageen
PublisherBentham Science Publishers
SubjectArab countries
Celiac disease
HLA
genetic susceptibility
gluten
incidence
prevalence
TitleImmunogenetics of Celiac Disease: A focus on Arab countries.
TypeArticle
dc.accessType Abstract Only


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