Proliposome tablets manufactured using a slurry-driven lipid-enriched powders: Development, characterization and stability evaluation
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Proliposome powders were prepared via a slurry method using sorbitol or D-mannitol as carbohydrate carriers in 1:10 or 1:15 w/w lipid phase to carrier ratios. Soya phosphatidylcholine (SPC) and cholesterol were employed as a lipid phase and Beclometasone dipropionate (BDP) was incorporated as a model drug. Direct compaction using a Minipress was applied on the lipid-enriched powder in order to manufacture proliposome tablets. Sorbitol-based proliposome tablets in a 1:15 w/w ratio were found to be the best formulation as it exhibited excellent powder flowability with an angle of repose of 25.62 � 1.08� and when compacted the resultant tablets had low friability (0.20 � 0.03%), appropriate hardness (crushing strength) (120.67 � 12.04 N), short disintegration time (5.85 � 0.66 min), and appropriate weight uniformity. Moreover, upon hydration into liposomes, the entrapment efficiency for sorbitol formulations in both 1:10 and 1:15 lipid to carrier ratios were significantly higher (53.82 � 6.42% and 57.43 � 9.12%) than D-mannitol formulations (39.90 � 4.30% and 35.22 � 6.50%), respectively. Extended stability testing was conducted for 18 months, at three different temperature conditions (Fridge Temperature (FT; 6 �C), Room Temperature (RT; 22 �C) and High Temperature (HT; 40 �C)) for sorbitol-based proliposome tablets (1:15 w/w ratio). Volume median diameter (VMD) and zeta potential significantly changed from 5.90 � 0.70 �m to 14.79 � 0.79 �m and from ?3.08 � 0.26 mV to ?11.97 � 0.26 mV respectively at month 18, when samples were stored under HT conditions. Moreover, the entrapment efficiency of BDP decreased from 57.43 � 9.12% to 17.93 � 5.37% following 18 months storage under HT conditions. Overall, in this study for the first time, proliposome tablets were manufactured and thoroughly characterized, and sorbitol showed to be a promising carrier. - 2018 Elsevier B.V.
- Pharmacy Research [279 items ]