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AuthorBhat, Ajaz A
AuthorYounes, Salma N
AuthorRaza, Syed Shadab
AuthorZarif, Lubna
AuthorNisar, Sabah
AuthorAhmed, Ikhlak
AuthorMir, Rashid
AuthorKumar, Sachin
AuthorSharawat, Surender K
AuthorHashem, Sheema
AuthorElfaki, Imadeldin
AuthorKulinski, Michal
AuthorKuttikrishnan, Shilpa
AuthorPrabhu, Kirti S
AuthorKhan, Abdul Q
AuthorYadav, Santosh K
AuthorEl-Rifai, Wael
AuthorZargar, Mohammad A
AuthorZayed, Hatem
AuthorHaris, Mohammad
AuthorUddin, Shahab
Available date2020-03-22T08:13:43Z
Publication Date2020-03-01
Publication NameMolecular Cancer
Identifierhttp://dx.doi.org/10.1186/s12943-020-01175-9
CitationBhat, A.A., Younes, S.N., Raza, S.S. et al. Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Mol Cancer 19, 57 (2020). https://doi.org/10.1186/s12943-020-01175-9
IdentifierArticle number: 57
URIhttp://hdl.handle.net/10576/13472
AbstractEarly-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate.Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.
Languageen
PublisherBMC
SubjectCancer
SubjectChromatin
SubjectCircular RNAs
SubjectDrug resistance
SubjectEpigenetics
SubjectGene regulation
SubjectLong non-coding RNAs
SubjectMetastasis
SubjectMicroRNAs
SubjectSignaling pathways
TitleRole of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
TypeArticle Review
Volume Number19
ESSN1476-4598


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