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AuthorCheng X.
AuthorHuang L.
AuthorYang X.
AuthorElzatahry A.A.
AuthorAlghamdi A.
AuthorDeng Y.
Available date2020-04-25T01:02:22Z
Publication Date2019
Publication NameJournal of Colloid and Interface Science
ResourceScopus
ISSN219797
URIhttp://dx.doi.org/10.1016/j.jcis.2018.09.101
URIhttp://hdl.handle.net/10576/14492
AbstractOwing to the high costs and instability of natural enzymes, the development of enzyme mimics based on inorganic nanomaterials has attracted a wide concern in recent years. In this work, a stable nanocomposite composed of highly dispersed CeO2 nanoparticles decorated on zeolite Y as support (CeO2/Y) was synthesized by a facile wet impregnation method, and the CeO2/Y nanocomposite was firstly proposed as an efficient peroxidase-mimicking nanozyme for accurate detection of H2O2 and glucose. The best catalyst was the nanocomposite with CeO2 to zeolite Y mass ratio of 0.20 (denoted as 20CeO2/Y), showing a better affinity and higher catalytic constant to the substrate of H2O2 and 3,3′,5,5′-tetramethylbenzidine (TMB) than horseradish peroxidase (HRP) enzymes by the steady-state kinetic analysis. The enzyme-mimicking catalyst could be used over a wider range of pH and temperature for a long-time reuse in TMB oxidation. A facile colorimetric assay was set up for the accurate detection of H2O2 and glucose, with the detection limits of 0.323 μM and 35.4 μM, respectively. The CeO2/Y-based peroxidase mimic was used to precisely detect the glucose concentration in real blood serum samples, exhibiting a great potential to be constructed as a reliable biosensor for glucose detection in some complex systems. The superior peroxidase-mimicking performance of CeO2/Y nanocomposite is attributed to the synergistic effects of outstanding activity of highly dispersed CeO2 nanoparticles (5–10 nm) and adsorption properties of zeolite Y with large surface area (517 m2·g−1) and pore volume (0.329 cm3·g−1).
SponsorThis work was sponsored by Shanghai Pujiang Program , China (No. 16PJ1401100 ), and the Shanghai Committee of Science and Technology , China (No. 15ZR1402000 ), Key Basic Research Program of Science and Technology Commission of Shanghai Municipality ( 17JC1400100 ), the NSF of China (51372041 , 51422202 , 21673048 , and 21875044 ), Youth Top-notch Talent Support Program of China.
Languageen
PublisherAcademic Press Inc.
SubjectCeO2/Y nanocomposite
Colorimetric
Glucose detection
H2O2
Nanozyme
Peroxidase mimic
TitleRational design of a stable peroxidase mimic for colorimetric detection of H2O2 and glucose: A synergistic CeO2/Zeolite Y nanocomposite
TypeArticle
Pagination425-435
Volume Number535
dc.accessType Abstract Only


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