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المؤلفGiordo, Roberta
المؤلفNasrallah, Gheyath
المؤلفAl-Jamal, Ola
المؤلفPaliogiannis, Panagiotis
المؤلفPintus, Gianfranco
تاريخ الإتاحة2020-05-31T05:08:44Z
تاريخ النشر2020-05
اسم المنشورInternational Journal of Molecular Sciences
المعرّفhttp://dx.doi.org/10.3390/ijms21113838
الاقتباسGiordo, R.; Nasrallah, G.K.; Al-Jamal, O.; Paliogiannis, P.; Pintus, G. Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio). Int. J. Mol. Sci. 2020, 21, 3838.
الرقم المعياري الدولي للكتاب1661-6596
معرّف المصادر الموحدhttp://hdl.handle.net/10576/14978
الملخصDespite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity.
اللغةen
الناشرMDPI
الموضوعresveratrol
nanoparticles
ROS
oxidative stress
antioxidants
mitochondria
zebrafish
zinc oxide
العنوانResveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)
النوعArticle
رقم العدد11
رقم المجلد21
ESSN1422-0067
dc.accessType Open Access


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