GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
المؤلف | Al-Jaber, Hend |
المؤلف | Al-Mansoori, Layla |
المؤلف | Elrayess, Mohamed A |
تاريخ الإتاحة | 2020-08-09T07:17:58Z |
تاريخ النشر | 2020-07-01 |
اسم المنشور | Current Diabetes Reviews |
المعرّف | http://dx.doi.org/10.2174/1573399816666200705210417 |
الاقتباس | Hend Al-Jaber, Layla Al-Mansoori and Mohamed A Elrayess*, “GATA-3 as a Potential Therapeutic Target for Insulin Resistance and Type 2 Diabetes Mellitus”, Current Diabetes Reviews (2020) 16: 1. https://doi.org/10.2174/1573399816666200705210417 |
الرقم المعياري الدولي للكتاب | 1573-3998 |
الملخص | Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was identified as one of the potential molecular targets responsible for impairment of adipogenesis. The expression of GATA-3 is higher in insulin resistant obese individuals compared to BMI-matched insulin sensitive counterparts. Adipose tissue inflammation is a crucial mediator of this process. Hyperglycemia mediates the activation of immune system, partially through upregulation of GATA-3, causing exacerbation of the inflammatory state associated with obesity. This review discusses evidence supporting the inhibition of GATA-3 as a useful therapeutic strategy in obesity-associated insulin resistance and type 2 diabetes, through up-regulation adipogenesis and amelioration of the immune response. |
راعي المشروع | This research was sponsored by QNRF; Grant no. UREP26-038-3-015 (MAE). Qatar National Library (QNL) has funded the publication of this article. |
اللغة | en |
الناشر | PubMed Central |
الموضوع | Adipogenesis GATA-3 Inflammation Insulin resistance Therapeutic target |
النوع | Article Review |
رقم العدد | 1 |
رقم المجلد | 16 |
ESSN | 1875-6417 |
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