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AuthorAl-Jaber, Hend
AuthorAl-Mansoori, Layla
AuthorElrayess, Mohamed A
Available date2020-08-09T07:17:58Z
Publication Date2020-07-01
Publication NameCurrent Diabetes Reviews
Identifierhttp://dx.doi.org/10.2174/1573399816666200705210417
CitationHend Al-Jaber, Layla Al-Mansoori and Mohamed A Elrayess*, “GATA-3 as a Potential Therapeutic Target for Insulin Resistance and Type 2 Diabetes Mellitus”, Current Diabetes Reviews (2020) 16: 1. https://doi.org/10.2174/1573399816666200705210417
ISSN1573-3998
URIhttp://hdl.handle.net/10576/15422
AbstractImpaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was identified as one of the potential molecular targets responsible for impairment of adipogenesis. The expression of GATA-3 is higher in insulin resistant obese individuals compared to BMI-matched insulin sensitive counterparts. Adipose tissue inflammation is a crucial mediator of this process. Hyperglycemia mediates the activation of immune system, partially through upregulation of GATA-3, causing exacerbation of the inflammatory state associated with obesity. This review discusses evidence supporting the inhibition of GATA-3 as a useful therapeutic strategy in obesity-associated insulin resistance and type 2 diabetes, through up-regulation adipogenesis and amelioration of the immune response.
SponsorThis research was sponsored by QNRF; Grant no. UREP26-038-3-015 (MAE). Qatar National Library (QNL) has funded the publication of this article.
Languageen
PublisherPubMed Central
SubjectAdipogenesis
GATA-3
Inflammation
Insulin resistance
Therapeutic target
TitleGATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
TypeArticle Review
Issue Number1
Volume Number16
ESSN1875-6417
dc.accessType Abstract Only


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