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AuthorAthanasiadou, Ioanna
AuthorVoss, Sven Christian
AuthorEl Saftawy, Wesal
AuthorAl-Jaber, Hind
AuthorDbes, Najib
AuthorAl-Yazedi, Sameera
AuthorSamsam, Waseem
AuthorMohamed-Ali, Vidya
AuthorAlsayrafi, Mohammed
AuthorValsami, Georgia
AuthorGeorgakopoulos, Costas
Available date2020-08-18T08:34:46Z
Publication Date2019
Publication NameInternational Journal of Sport Nutrition and Exercise Metabolism
ResourceScopus
ISSN1526484X
URIhttp://dx.doi.org/10.1123/ijsnem.2018-0213
URIhttp://hdl.handle.net/10576/15677
AbstractLow urinary luteinizing hormone (LH) values have been discussed as a marker to detect steroid abuse. However, suppressed LH concentrations related to highly diluted urine samples could be a misleading indication of anabolic steroid abuse. One aim of the present study was to examine the effect of hyperhydration on the interpretation of LH findings during doping control analysis and to investigate different possibilities to correct volume-related changes in urinary LH concentrations. Seven healthy, physically active, nonsmoking White males were examined for a 72-hr period, using water and a commercial sports drink as hyperhydration agents (20 ml/kg body weight). Urine samples were collected and analyzed according to the World Anti-Doping Agency's technical documents. Baseline urinary LH concentrations, expressed as the mean � SD for each individual, were within the acceptable physiological range (7.11 � 5.42 IU/L). A comparison of the measured LH values for both hyperhydration phases (Phase A: 4.24 � 5.60 IU/L and Phase B: 4.74 � 4.72 IU/L) with the baseline (''normal'') values showed significant differences (Phase A: p < .001 and Phase B: p < .001), suggesting the clear effect of urine dilution due to hyperhydration. However, an adjustment of urinary LH concentrations by specific gravity based on a reference value of 1.020 seems to adequately correct the hyperhydration-induced decrease on the LH levels. - 2019 Human Kinetics, Inc.
SponsorThe authors sincerely thank the World Anti-Doping Agency for the financial support of the project (contract 10D21CG). Furthermore, the authors would like to acknowledge the medical staff of Al-Hayat Medical Center, Doha, Qatar, for their help during the clinical part of the project performed under the supervision of Dr. Khaled Youssef, MD and Dr. Fawaz Amin Saad, MD. Finally, Mrs. Noor Al-Motawa, ADLQ Education and Research Office Director, is sincerely acknowledged for her constant support on the research projects. The authors have no conflict of interest to declare.
Languageen
PublisherHuman Kinetics Publishers Inc.
SubjectEndogenous substances
Excessive fluid intake
Masking
Specific gravity
Urinary excretion
TitleHyperhydration-induced decrease in urinary luteinizing hormone concentrations of Male athletes in doping control analysis
TypeArticle
Pagination388-396
Issue Number4
Volume Number29
dc.accessType Abstract Only


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