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المؤلفShurbaji, Samar
المؤلفAl-Ruweidi, Mahmoud Khatib A.A.
المؤلفAli, Fatma Hassan
المؤلفBenslimane, Fatiha M.
المؤلفYalcin, Huseyin C.
تاريخ الإتاحة2020-10-15T05:12:59Z
تاريخ النشر2020
اسم المنشورMethods and Protocols
المعرّفhttp://dx.doi.org/10.3390/mps3040065
الاقتباسShurbaji S, Al-Ruweidi MKAA, Ali FH, Benslimane FM, Yalcin HC. Application of a Flow-Induced Stress Wave and Investigation of Associated Injuries on Cell Monolayers Using a Parallel Plate Flow Chamber. Methods Protoc. 2020;3(4):E65. Published 2020 Sep 24. doi:10.3390/mps3040065
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85091489157&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16451
الملخص© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications usually involve the generation of continuous and steady fluid flow over cell monolayers for extended durations, usually a few days. Another technique is to generate a fast high-stress wave over the cells to see the immediate effect of flow-induced stresses. This can be achieved by propagating an air/liquid interface, in other words, a bubble, over cell monolayers. The approach is relevant to the reopening event of fluid-filled lung bronchioles and alveoli during mechanical ventilation therapy of Acute Respiratory Distress Syndrome. This article explains how we generate a stress wave using a parallel plate flow chamber and presents representative results of this wave on cultured lung epithelial cells.
اللغةen
الناشرMDPI
الموضوعBubble
Cell injuries
Endothelial cells
Epithelial cells
Flow
Hemodynamics
Parallel plate flow chamber
Stress
Viability
العنوانApplication of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber
النوعArticle
رقم العدد4
رقم المجلد3
ESSN2409-9279
dc.accessType Open Access


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