تصفح COVID-19 Research حسب المؤلف "Yassine, Hadi M."

السجلات المعروضة 21 -- 40 من 77

    • Duration of immune protection of SARS-CoV-2 natural infection against reinfection. 

      Chemaitelly, Hiam; Nagelkerke, Nico; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; ... more authors ( Oxford University Press , 2022 , Article)
      The future of the SARS-CoV-2 pandemic hinges on virus evolution and duration of immune protection of natural infection against reinfection. We investigated duration of protection afforded by natural infection, the effect ...

    • Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar. 

      Chemaitelly, Hiam; Ayoub, Houssein H; AlMukdad, Sawsan; Coyle, Peter; Tang, Patrick; ... more authors ( Nature Research , 2022 , Article)
      SARS-CoV-2 Omicron BA.1 and BA.2 subvariants are genetically divergent. We conducted a matched, test-negative, case-control study to estimate duration of protection of the second and third/booster doses of mRNA COVID-19 ...

    • Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar. 

      Abu-Raddad, Laith J; Chemaitelly, Hiam; Ayoub, Houssein H; AlMukdad, Sawsan; Yassine, Hadi M; ... more authors ( Massachusetts Medical Society , 2022 , Article)
      Waning of vaccine protection against coronavirus disease 2019 (Covid-19) and the emergence of the omicron (or B.1.1.529) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to expedited ...

    • Effect of multiple freeze–thaw cycles on the detection of anti-SARS- CoV- 2 IgG antibodies 

      Shurrab, Farah M; Al-Sadeq, Duaa W.; Amanullah, Fathima; Younes, Salma N.; Al-Jighefee, Hadeel; ... more authors ( Microbiology Society , 2021 , Article)
      Several studies have investigated the effect of repeated freeze-thaw (F/T) cycles on RNA detection for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, no data are available regarding the effect of ...

    • Effectiveness of two and three doses of COVID-19 mRNA vaccines against infection, symptoms, and severity in the pre-omicron era: A time-dependent gradient 

      Layan, Sukik; Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; ... more authors ( Elsevier , 2024 , Article)
      BackgroundVaccines were developed and deployed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to characterize patterns in the protection provided by the BNT162b2 and ...

    • Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections. 

      Qassim, Suelen H; Chemaitelly, Hiam; Ayoub, Houssein H; AlMukdad, Sawsan; Tang, Patrick; ... more authors ( Oxford University Press , 2022 , Article)
      Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value-3.53 fewer cycles (95% CI: 3.46-3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of ...

    • Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections. 

      Altarawneh, Heba N; Chemaitelly, Hiam; Ayoub, Houssein H; Tang, Patrick; Hasan, Mohammad R; ... more authors ( Massachusetts Medical Society , 2022 , Article)
      The protection conferred by natural immunity, vaccination, and both against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the BA.1 or BA.2 sublineages of the omicron (B.1.1.529) ...

    • Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections 

      Qassim, Suelen H.; Hasan, Mohammad R.; Tang, Patrick; Chemaitelly, Hiam; Ayoub, Houssein H.; ... more authors ( Frontiers Media , 2022 , Article)
      In 2021, Qatar experienced considerable incidence of SARS-CoV-2 infection that was dominated sequentially by the Alpha, Beta, and Delta variants. Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy ...

    • Enhancing the sensitivity of rapid antigen detection test (RADT) of different SARS-CoV-2 variants and lineages using fluorescence-labeled antibodies and a fluorescent meter 

      Gheyath K., Nasrallah; Ali, Fatma; Younes, Salma; Al Khatib, Heba A.; Al-Thani, Asmaa A.; ... more authors ( Elsevier , 2023 , Article)
      RT-qPCR is considered the gold standard for diagnosis of COVID-19; however, it is laborious, time-consuming, and expensive. RADTs have evolved recently as relatively inexpensive methods to address these shortcomings, but ...

    • Epidemiological impact of prioritising SARS-CoV-2 vaccination by antibody status: Mathematical modelling analyses 

      Ayoub, H.H.; Ayoub, Houssein H.; Chemaitelly, Hiam; Makhoul, Monia; Al Kanaani, Zaina; ... more authors ( BMJ Publishing Group , 2021 , Article)
      Background Vaccines against SARS-CoV-2 have been developed, but their availability falls far short of global needs. This study aimed to investigate the impact of prioritising available doses on the basis of recipient ...

    • Epidemiology of SARS-CoV2 in Qatar's primary care population aged 10 years and above 

      Syed, Mohamed Ahmed; Al Nuaimi, Ahmed Sameer; A/Qotba, Hamda Abdulla; Nasrallah, Gheyath K; Althani, Asmaa A; ... more authors ( BMC , 2021 , Article)
      There is an urgent need to elucidate the epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and characterize its potential impact. Investing in characterising the SARS-CoV2 will help plan and ...

    • Evaluation of antibody response in symptomatic and asymptomatic covid-19 patients and diagnostic assessment of new IgM/IgG elisa kits 

      Al-Jighefee, Hadeel T.; Yassine, Hadi M.; Nasrallah, Gheyath K. ( MDPI , 2021 , Article)
      © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This study aims to study the immune response and evaluate the performances of four new IgM and five IgG enzyme-linked immunosorbent assay (ELISA) kits for detecting ...

    • Evaluation of commercially available fully automated and ELISA-based assays for detecting anti-SARS-CoV-2 neutralizing antibodies 

      Zedan, Hadeel T.; Yassine, Hadi M.; Al-Sadeq, Duaa W.; Liu, Na; Qotba, Hamda; ... more authors ( Nature Research , 2022 , Article)
      Rapid and accurate measurement of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-specific neutralizing antibodies (nAbs) is paramount for monitoring immunity in infected and vaccinated subjects. The current ...

    • Evaluation of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for detecting SARS-CoV-2 in clinical, environmental and animal samples. 

      Benslimane, Fatiha M.; Al-Jamal, Ola; Boughattas, Sonia|Al Thani, Asmaa A; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)
      Background: First described 20 years ago by Notomi et al., the loop-mediated isothermal amplification (LAMP) assay is robust, rapid and straightforward, yet retains high sensitivity and specificity. These features have ...

    • Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months 

      Salma, Younes; Nicolai, Eleonora; Al-Sadeq, Duaa W.; Younes, Nadin; Al-Dewik, Nader; ... more authors ( Elsevier , 2023 , Article)
      BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ...

    • Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis 

      Smatti, Maria K.; Al-Sarraj, Yasser; Albagha, Omar; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)
      Background: Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly ...

    • Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. 

      Smatti, Maria K; Al-Sarraj, Yasser A; Albagha, Omar; Yassine, Hadi M ( Frontiers Media , 2020 , Article)
      Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly due to host ...

    • Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach 

      Mathew, Shilu Mathew; Benslimane, Fatiha; Althani, Asmaa A; Yassine, Hadi M ( Hamad Bin Khalifa University Press , 2021 , Article)
      The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The spike ...

    • Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2 

      Diboun, I.; Diboun, Ilhame; Cyprian, Farhan S.; Anwardeen, Najeha Rizwana; Yassine, Hadi M.; ... more authors ( Frontiers Media S.A. , 2022 , Article)
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection currently remains one of the biggest global challenges that can lead to acute respiratory distress syndrome (CARDS) in severe cases. In line with this, ...

    • Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Hasan, Mohammad R.; Coyle, Peter; ... more authors ( Massachusetts Medical Society , 2022 , Other)
      More than 2 years into the coronavirus disease 2019 (Covid-19) pandemic, the global population carries heterogeneous immune histories derived from various exposures to infection, viral variants, and vaccination.1 Evidence ...