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    Validation of Selected Commercial Serological Assays for Diagnosis of COVID-19

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    Validation of Selected Commercial Serological Assays for Diagnosis of COVID-19.pdf (4.997Mb)
    Date
    2020
    Author
    Younes, Salma
    Al-Jighefee, Hadeel
    Shurrab, Farah
    Al-Sadeq, Duaa
    Yassine, Hadi
    Althani, Asmaa
    Marei, Reham
    Alhussain, Hashim
    Nasrallah, Gheyath
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    Abstract
    As researchers around the globe rush to put the available antibody tests to use, concerns have been raised about their precision. This study aimed to evaluate and compare the performance of selected commercial & automated serological assays, that are widely used in different clinical settings in Qatar. We validated the performance of five commercial IgG and IgM ELISA kits, three fully automated immunoassays, and two commercial rapid tests. The sensitivity of all assays was compared to RT-PCR and a surrogate virus neutralization test (sVNT). In addition, cross-reactivity was investigated. Among the evaluated kits, Lionex IgG assaydemonstrated the best performance (~88% sensitivity and ~99 specificity). All automated assays showed an excellent correlation with the neutralization test with an overall agreement of 93.6-98.5%. The rapid assays demonstrated a very good performance in detecting IgG antibodies (86.0-88.0% sensitivity and 98.0-100% specificity).
    URI
    https://doi.org/10.29117/quarfe.2020.0306
    DOI/handle
    http://hdl.handle.net/10576/16530
    Collections
    • COVID-19 Research [‎848‎ items ]
    • Theme 5: Covid-19 Research [‎32‎ items ]

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