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AuthorYounes, Salma
AuthorAl-Jighefee, Hadeel
AuthorShurrab, Farah
AuthorAl-Sadeq, Duaa
AuthorYassine, Hadi
AuthorAlthani, Asmaa
AuthorMarei, Reham
AuthorAlhussain, Hashim
AuthorNasrallah, Gheyath
Available date2020-10-22T06:07:20Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationYounes S., AlJighefee H., Shurrab F., AlSadeq D., Yassine H., Althani A., Marei R., Alhussain H., Nasrallah G., "Validation of Selected Commercial Serological Assays for Diagnosis of COVID-19", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0306
URIhttps://doi.org/10.29117/quarfe.2020.0306
URIhttp://hdl.handle.net/10576/16530
AbstractAs researchers around the globe rush to put the available antibody tests to use, concerns have been raised about their precision. This study aimed to evaluate and compare the performance of selected commercial & automated serological assays, that are widely used in different clinical settings in Qatar. We validated the performance of five commercial IgG and IgM ELISA kits, three fully automated immunoassays, and two commercial rapid tests. The sensitivity of all assays was compared to RT-PCR and a surrogate virus neutralization test (sVNT). In addition, cross-reactivity was investigated. Among the evaluated kits, Lionex IgG assaydemonstrated the best performance (~88% sensitivity and ~99 specificity). All automated assays showed an excellent correlation with the neutralization test with an overall agreement of 93.6-98.5%. The rapid assays demonstrated a very good performance in detecting IgG antibodies (86.0-88.0% sensitivity and 98.0-100% specificity).
Languageen
PublisherQatar University Press
SubjectSerology
SubjectCOVID-19
SubjectDiagnosis
TitleValidation of Selected Commercial Serological Assays for Diagnosis of COVID-19
TypePoster


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