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AuthorAhmed, Elham
AuthorKhan, Abdul
AuthorS.Prabhu, Kirti
AuthorSiveen, Kodappully
AuthorNawaz, Zafar
AuthorZayed, Hatem
AuthorUddin, Shahab
Available date2020-10-26T08:49:54Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationAhmed E., Khan A., Prabhu S.K., Siveen K., Nawaz Z., Zayed H., Uddin S., " Sanguinarine mediated anti-tumor activity via targeting JAK/STAT3 pathway in thyroid cancer", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0155
URIhttps://doi.org/10.29117/quarfe.2020.0155
URIhttp://hdl.handle.net/10576/16738
AbstractSanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. This research aimed to investigate the antiproliferative and anti-cancer potential of SNG against two well characterized papillary thyroid cancer (PTC) cell lines, BCPAP and TPC-1 .In both cell lines , SNG was able to inhibit cell proliferation in time and dose dependent manner. Western blot analysis revealed increased expression of apoptosis and autophagy markers , caspase-3,cleaved caspase-3 , P62, and LC3. SNG modulate its anticancer effect through ROS production, because NAC was able to reverse SNG effect. Interestingly, co-treatment of PTC with SNG and cisplatin amplified anticancer activity. Finally, SNG treatment of PTC spheroid suppressed its growth with downregulation of stemness markers including ALDH2 and SOX2 markers. In conclusion, SNG enhanced the anti cancer activity against PTC cells and the effect is amplified when cisplatin is added.
Languageen
PublisherQatar University Press
SubjectSanguinarine
SubjectJAK/STAT3 Pathway
SubjectThyroid Cancer
TitleSanguinarine mediated anti-tumor activity via targeting JAK/STAT3 pathway in thyroid cancer
TypePoster


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