Quantifying Gut Microbiome in Rats with Adenine-Induced Chronic Kidney Disease and the Effect of Treatment with Gum Arabic

Abstract

Chronic kidney disease (CKD) affects ~10% of Qatar's population. Recently, dysbiosis in the gut microbiome has been associated with CKD. It is not understood whether CKD affects the gut microbiome or the dysbiotic gut microbiome leads to CKD. Gum Arabic (GA) is a fiber-rich dietary substance that has a potential to enhance the gut microbiome, therefore it could treat CKD. The Aim of this study is to quantify the gut microbiome in CKD rats and to evaluate the GA as a potential treatment for CKD.