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AuthorKamareddine, Layla
AuthorNajjar, Hoda
AuthorAbdulkader, Hadil
AuthorAl-Asmakh, Maha
AuthorSohail, Muhammad Umar
Available date2020-11-03T06:09:20Z
Publication Date2020-11-02
Publication NameCells
Identifierhttp://dx.doi.org/10.3390/cells9112401
CitationKamareddine, L.; Najjar, H.; Sohail, M.U.; Abdulkader, H.; Al-Asmakh, M. The Microbiota and Gut-Related Disorders: Insights from Animal Models. Cells 2020, 9, 2401.
URIhttp://hdl.handle.net/10576/16858
AbstractOver the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions of microbes that exhibit various roles including the production of vitamins, absorption of nutrients, pathogen displacement, and development of the host immune system, particular attention has been given to the use of germ-free (GF) animal models in unraveling the effect of the gut microbiota on the physiology and pathophysiology of the host. In this review, we discuss common methods used to generate GF fruit fly, zebrafish, and mice model systems and highlight the use of these GF model organisms in addressing the role of gut-microbiota in gut-related disorders (metabolic diseases, inflammatory bowel disease, and cancer), and in activating host defense mechanisms and amending pathogenic virulence.
SponsorThe authors are supported by internal grants from Qatar University (QUCP-CHS-2019-1).
Languageen
PublisherMDPI
Subjectanimal models
germ-free
gut microbiota
gut-related disorders
host–defense
pathogen virulence
TitleThe Microbiota and Gut-Related Disorders: Insights from Animal Models
TypeArticle Review
Issue Number11
Volume Number9
ESSN2073-4409
dc.accessType Open Access


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