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AuthorSohail, Muhammad U.
AuthorAl-Mansoori, Layla
AuthorAl-Jaber, Hend
AuthorGeorgakopoulos, Costas
AuthorDonati, Francesco
AuthorBotrè, Francesco
AuthorSellami, Maha
AuthorElrayess, Mohamed A.
Available date2020-11-12T09:04:13Z
Publication Date2020-10-15
Publication NameFrontiers in Physiology
Identifierhttp://dx.doi.org/10.3389/fphys.2020.600888
CitationSohail MU, Al-Mansoori L, Al-Jaber H, Georgakopoulos C, Donati F, Botrè F, Sellami M and Elrayess MA (2020) Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines. Front. Physiol. 11:600888. doi: 10.3389/fphys.2020.600888
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85094645622&origin=inward
URIhttp://hdl.handle.net/10576/16984
Abstract© Copyright © 2020 Sohail, Al-Mansoori, Al-Jaber, Georgakopoulos, Donati, Botrè, Sellami and Elrayess. Objectives: Circulating cytokines and oxidative stress markers vary in response to different exercise regimens. This study aims to compare the immune-inflammatory and oxidative stress profiles of elite athletes from different sport disciplines as potential biomarkers of muscle damage, and cardiovascular demand. Methods: Serum samples from 88 consented elite male athletes from different sports disciplines (aquatics, n = 11, athletics, n = 22, cycling, n = 19, football, n = 28 and weightlifting, n = 8) collected at the anti-doping lab in Italy were screened for 38 cytokines and oxidative stress markers. Comparisons were made between different level of power, cardiovascular demand (CD) and endurance, as well as among the sport types. Results: The anti-inflammatory interleukin (IL)-10 was higher (p = 0.04) in moderate power compared with the high power group. Conversely, superoxide dismutase (SOD; p = 0.001) and malondialdehyde (MDA; p = 0.007) levels were greater in the higher power groups compared with the lower power counterpart. Among athletes who belong to different CD ranks, IL-1β and monocyte chemoattractant protein-1(MCP1) levels were higher (p = 0.03) in the low CD-rank group compared with high CD counterpart, whereas, SOD levels were higher (p = 0.001) in high and moderate CD-rank groups compared to low counterpart. For endurance groups, IL-10 and macrophage inflammatory protein (MIP)-1beta were increased (p = 0.03) in low/moderate endurance compared with the high endurance group. Finally, MIP1-beta, SOD and catalase varied significantly among the sports groups. Conclusion: Specific markers of inflammation and oxidative stress are associated with different sports disciplines and could be utilized as potential biomarkers of athletes’ health, performance, and recovery from injury.
SponsorWe would like to thank Qatar National Research Fund (QNRF) for funding this project.
Languageen
PublisherFrontiers Media
Subjectbiomarkers
cardiovascular demand
cytokines
elite athletes
endurance
oxidative stress
power
TitleAssessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines
TypeArticle
Volume Number11
ESSN1664-042X
dc.accessType Open Access


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