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المؤلفAl-Asmakh, Maha
المؤلفMajdalawieh, Amin F.
المؤلفAbdullah, Aboubakr M.
المؤلفYounes, Nadin
المؤلفDa’as, Sahar I.
المؤلفRadwan, A. Bahgat
المؤلفSliem, Mostafa H.
المؤلفEch-Cherif, Houria
المؤلفPintus, Gianfranco
المؤلفNasrallah, Gheyath K.
تاريخ الإتاحة2020-11-22T06:07:14Z
تاريخ النشر2020-12-01
اسم المنشورEnvironmental Sciences Europe
المعرّفhttp://dx.doi.org/10.1186/s12302-020-00429-z
الاقتباسAl-Asmakh, M., Majdalawieh, A.F., Abdullah, A.M. et al. AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos. Environ Sci Eur 32, 149 (2020). https://doi.org/10.1186/s12302-020-00429-z
الرقم المعياري الدولي للكتاب2190-4707
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095821515&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/17015
الملخص© 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7, especially towards aquatic organisms, is a major impediment to its wider application. Here, we assess potential adverse effects of AEO-7 on zebrafish embryos employing a variety of assays, including (i) a mortality/survival assay which allowed the median lethal concentration (LC50) to be calculated; (ii) a teratogenicity assay on the basis of which the no observed effect concentration (NOEC) was determined; and (iii) specific assays of cardiotoxicity, neurotoxicity (based on locomotion), hematopoietic toxicity (the level of hemoglobin as revealed by o-dianisidine staining) and hepatotoxicity (liver steatosis and yolk retention examined by staining with Oil Red O). Results: AEO-7 caused mortality with a calculated LC50 of 15.35 μg/L, which, according to the U.S. Fish and Wildlife Service (USFWS) Acute Toxicity Rating scale, should be considered “super toxic”. Although at its NOEC (0.8 μg/L), there were no signs of significant teratogenicity, cardiotoxicity, or hemopoiesis toxicity, 3.2 µg/L AEO-7 exerted dramatic detrimental effects on organ development. Conclusion: On the basis of these findings, we recommend that the industrial usage and environmental impact of AEO-7 be re-evaluated and strictly monitored by environmental and public health organizations.
اللغةen
الناشرSpringerOpen
الموضوعAEO-7 surfactant
Cardiotoxicity
Hepatotoxicity
Neurotoxicity
Zebrafish embryos
العنوانAEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
النوعArticle
رقم العدد1
رقم المجلد32
ESSN2190-4715
dc.accessType Open Access


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