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AuthorAl-Asmakh, Maha
AuthorMajdalawieh, Amin F.
AuthorAbdullah, Aboubakr M.
AuthorYounes, Nadin
AuthorDa’as, Sahar I.
AuthorRadwan, A. Bahgat
AuthorSliem, Mostafa H.
AuthorEch-Cherif, Houria
AuthorPintus, Gianfranco
AuthorNasrallah, Gheyath K.
Available date2020-11-22T06:07:14Z
Publication Date2020-12-01
Publication NameEnvironmental Sciences Europe
Identifierhttp://dx.doi.org/10.1186/s12302-020-00429-z
CitationAl-Asmakh, M., Majdalawieh, A.F., Abdullah, A.M. et al. AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos. Environ Sci Eur 32, 149 (2020). https://doi.org/10.1186/s12302-020-00429-z
ISSN2190-4707
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095821515&origin=inward
URIhttp://hdl.handle.net/10576/17015
Abstract© 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7, especially towards aquatic organisms, is a major impediment to its wider application. Here, we assess potential adverse effects of AEO-7 on zebrafish embryos employing a variety of assays, including (i) a mortality/survival assay which allowed the median lethal concentration (LC50) to be calculated; (ii) a teratogenicity assay on the basis of which the no observed effect concentration (NOEC) was determined; and (iii) specific assays of cardiotoxicity, neurotoxicity (based on locomotion), hematopoietic toxicity (the level of hemoglobin as revealed by o-dianisidine staining) and hepatotoxicity (liver steatosis and yolk retention examined by staining with Oil Red O). Results: AEO-7 caused mortality with a calculated LC50 of 15.35 μg/L, which, according to the U.S. Fish and Wildlife Service (USFWS) Acute Toxicity Rating scale, should be considered “super toxic”. Although at its NOEC (0.8 μg/L), there were no signs of significant teratogenicity, cardiotoxicity, or hemopoiesis toxicity, 3.2 µg/L AEO-7 exerted dramatic detrimental effects on organ development. Conclusion: On the basis of these findings, we recommend that the industrial usage and environmental impact of AEO-7 be re-evaluated and strictly monitored by environmental and public health organizations.
Languageen
PublisherSpringerOpen
SubjectAEO-7 surfactant
Cardiotoxicity
Hepatotoxicity
Neurotoxicity
Zebrafish embryos
TitleAEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
TypeArticle
Issue Number1
Volume Number32
ESSN2190-4715
dc.accessType Open Access


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