Show simple item record

AuthorYounes, Salma
AuthorYounes, Nadin
AuthorShurrab, Farah
AuthorNasrallah, Gheyath K
Available date2020-11-22T07:02:31Z
Publication Date2020-11-01
Publication NameReviews in Medical Virology
Identifierhttp://dx.doi.org/10.1002/rmv.2196
CitationYounes, S., Younes, N., Shurrab, F. and Nasrallah, G.K. (2020), Severe acute respiratory syndrome coronavirus‐2 natural animal reservoirs and experimental models: systematic review. Rev Med Virol e2196. https://doi.org/10.1002/rmv.2196
ISSN1052-9276
URIhttp://hdl.handle.net/10576/17017
AbstractThe current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak has been rapidly spreading worldwide, causing serious global concern. The role that animal hosts play in disease transmission is still understudied and researchers wish to find suitable animal models for fundamental research and drug discovery. In this systematic review, we aimed to compile and discuss all articles that describe experimental or natural infections with SARS-CoV-2, from the initial discovery of the virus in December 2019 through to October 2020. We systematically searched four databases (Scopus, PubMed, Science Direct and Web of Science). The following data were extracted from the included studies: type of infection (natural or experimental), age, sample numbers, dose, route of inoculation, viral replication, detection method, clinical symptoms and transmission. Fifty-four studies were included, of which 34 were conducted on animal reservoirs (naturally or experimentally infected), and 20 involved models for testing vaccines and therapeutics. Our search revealed that Rousettus aegyptiacus (fruit bats), pangolins, felines, mink, ferrets and rabbits were all susceptible to SARS-CoV-2, while dogs were weakly susceptible and pigs, poultry, and tree shrews were not. In addition, virus replication in mice, mink, hamsters and ferrets resembled subclinical human infection, so these animals might serve as useful models for future studies to evaluate vaccines or antiviral agents and to study host-pathogen interactions. Our review comprehensively summarized current evidence on SARS-CoV-2 infection in animals and their usefulness as models for studying vaccines and antiviral drugs. Our findings may direct future studies for vaccine development, antiviral drugs and therapeutic agents to manage SARS-CoV-2-caused diseases.
SponsorOpen access funding provided by the Qatar National Library. This report was made possible by an RRC award [RRC‐2‐032] from the Qatar National Research Fund (a member of The Qatar Foundation). The statements made herein are solely the responsibility of the authors.
Languageen
PublisherJohn Wiley and Sons
SubjectCovid-19
SARS-CoV-2
animal hosts
animal models
therapeutic agents
vaccines
TitleSevere acute respiratory syndrome coronavirus-2 natural animal reservoirs and experimental models: systematic review.
TypeArticle Review
ESSN1099-1654
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record