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AuthorWilby, Kyle John
AuthorNasr, Ziad Ghantous
AuthorElazzazy, Shereen
AuthorLau, Tim T. Y.
AuthorHamad, Anas
Available date2020-12-03T11:24:56Z
Publication Date2017
Publication NameDrugs in R and D
ResourceScopus
URIhttp://dx.doi.org/10.1007/s40268-017-0173-0
URIhttp://hdl.handle.net/10576/17192
AbstractMeropenem is a carbapenem antibiotic that exhibits time-dependent bactericidal activity, traditionally dosed intravenously at 1�g every 8�h. In order to maximize its pharmacodynamic activity and reduce costs, an alternative regimen employed by many institutions is 500�mg every 6�h. The objective of this review was to summarize and evaluate published literature comparing clinical outcomes associated with these two meropenem dosing regimens. The literature was searched up to October 2016 using the MEDLINE, EMBASE, and Google Scholar databases. Three retrospective cohort studies were identified that compared clinical outcomes in general infectious disease patients (two studies) and patients with febrile neutropenia (one study). All studies reported no difference in clinical outcomes (clinical success, time to defervescence, sign or symptom resolution, length of stay, mortality, need for other antibiotics, and seizure rates). One study reported reduced economic costs with the alternative dosing. Interpretation of findings was primarily limited by small sample sizes and generalizability. Based on the data reviewed, the alternative dosing regimen of meropenem 500�mg intravenously every 6�h could be considered a therapeutic option. Future studies are needed to confirm the findings of this review, especially in high-risk populations such as immunocompromised patients or those with severe infections.
Languageen
PublisherSpringer International Publishing
SubjectMeropenem
TitleA Review of Clinical Outcomes Associated with Two Meropenem Dosing Strategies
TypeArticle Review
Pagination73-78
Issue Number1
Volume Number17
dc.accessType Abstract Only


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