Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells
| Author | Hassani, A |
| Author | Hussain, S A |
| Author | Enezei, H H |
| Author | Saeed, S |
| Author | Ibrahim, W N |
| Author | Al-Qubaisi, M S |
| Author | Zentou, H |
| Author | Rosli, R |
| Author | Doolaanea, A A |
| Available date | 2021-01-03T08:33:10Z |
| Publication Date | 2020-12-22 |
| Publication Name | IOP Conference Series: Materials Science and Engineering (MSE) |
| Identifier | http://dx.doi.org/10.1088/1757-899X/991/1/012101 |
| Citation | A Hassani et al 2020 IOP Conf. Ser.: Mater. Sci. Eng. 991 012101 |
| ISSN | 1757-8981 |
| Abstract | Curcumin nanoparticles (Cur/GANPs) were formulated based on gum arabic (GA) as a stabilizer coatings for nanoparticles through efficient synthesis approach. The current study investigated the antioxidant properties and antihypertensive activity of curcumin (Cur) using various established in vitro assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as angiotensin converting enzyme (ACE) inhibitory activity. The in vitro cytotoxicity of Cur/GANPs against human liver cancer (HepG2), and colon cancer (HT29) was investigated. The exposure of human cancer cells to Cur/GANPs (1.56-100 µg/ml) using MTT (3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) has revealed that the Cur/GANPs inhibited the growth of cell lines examined in a dose dependent manner. Hence, Cur/GANPs nanoparticles may have great potential to be applied for cancer treatment. |
| Sponsor | The authors would like to acknowledge International Islamic University Malaysia and Universiti Putra Malaysia for awarding the funds to conduct this research under project number of P-RIGS18-026-0026 and GP-IPS/2016/9505500 |
| Language | en |
| Publisher | IOP Publishing |
| Subject | nanoparticles Cancer gum arabic |
| Type | Article |
| Volume Number | 991 |
| ESSN | 1757-899X |
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