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AuthorKawish, Muhammad
AuthorElhissi, Abdelbary
Authorjabri, Tooba
AuthorIqbal, Kanwal Muhammad
AuthorZahid, Hina
AuthorShah, Muhammad Raza
Available date2021-01-04T08:23:00Z
Publication Date2020-05-01
Publication NamePharmaceutics
Identifierhttp://dx.doi.org/10.3390/pharmaceutics12060492
CitationKawish M, Elhissi A, Jabri T, Iqbal KM, Zahid H, Shah MR. Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles. Pharmaceutics. 2020 May 28;12(6):492. doi: 10.3390/pharmaceutics12060492. PMID: 32481715; PMCID: PMC7355964.
URIhttp://hdl.handle.net/10576/17272
AbstractThe present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N'-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light scattering (DLS) showed that the developed CFT loaded MIH-MNPs are spherical, with a measured hydrodynamic size of 184.0 ± 2.7 nm and negative zeta potential values (-20.2 ± 0.4 mV). Fourier transformed infrared spectroscopic (FTIR) analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiency (EE) of 79.4% ±1.5%, and the drug was released gradually in vitro and showed prolonged in vitro stability using simulated gastrointestinal tract (GIT) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.4 ± 1.8 µg/mL in comparison with its control (2.0 ± 0.6 µg/mL). Overall, the developed CFT-MIH-MNPs formulation was promising for provision of high drug entrapment, gradual drug release and suitability for enhancing the oral delivery of CFT.
Languageen
PublisherMDPI
SubjectIron oxide nanoparticles
Surface functionalization
Biocompatibility
Ceftriaxone
Oral delivery
TitleEnhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles.
TypeArticle
Issue Number6
Volume Number12
ESSN1999-4923


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