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AuthorRamanjaneya, Manjunath
AuthorButler, Alexandra E
AuthorBashir, Mohammed
AuthorBettahi, Ilham
AuthorMoin, Abu Saleh Md
AuthorAhmed, Lina
AuthorElrayess, Mohamed A
AuthorHunt, Steven C
AuthorAtkin, Stephen L
AuthorAbou-Samra, Abdul Badi
Available date2021-03-09T07:19:04Z
Publication Date2021-03-01
Publication NameBMJ Open Diabetes Research and Care
Identifierhttp://dx.doi.org/10.1136/bmjdrc-2020-001925
CitationRamanjaneya M, Butler AE, Bashir M, et alapoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetesBMJ Open Diabetes Research and Care 2021;9:e001925. doi: 10.1136/bmjdrc-2020-001925
URIhttp://hdl.handle.net/10576/17877
AbstractPregnant women with gestational diabetes mellitus (GDM) are at risk of adverse outcomes, including gestational hypertension, pre-eclampsia, and preterm delivery. This study was undertaken to determine if apolipoprotein (apo) levels differed between pregnant women with and without GDM and if they were associated with adverse pregnancy outcome. Pregnant women (46 women with GDM and 26 women without diabetes (ND)) in their second trimester were enrolled in the study. Plasma apos were measured and correlated to demographic, biochemical, and pregnancy outcome data. apoA2, apoC1, apoC3 and apoE were lower in women with GDM compared with control women (p=0.0019, p=0.0031, p=0.0002 and p=0.015, respectively). apoA1, apoB, apoD, apoH, and apoJ levels did not differ between control women and women with GDM. Pearson bivariate analysis revealed significant correlations between gestational age at delivery and apoA2 for women with GDM and control women, and between apoA2 and apoC3 concentrations and C reactive protein (CRP) as a measure of inflammation for the whole group. Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. The fact that apoA2 correlated with gestational age at delivery in both control women and women with GDM raises the hypothesis that apoA2 may be used as a biomarker of premature delivery, and this warrants further investigation.
Languageen
PublisherBMJ Publishing Group
Subjectapolipoproteins
diabetes
diabetes mellitus
gestational
pregnancy
type 2
Apoproteins
GDM
Biomarker
TitleapoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes.
TypeArticle
Issue Number1
Volume Number9
ESSN2052-4897
dc.accessType Open Access


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