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AuthorMoin, Abu Saleh Md
AuthorSathyapalan, Thozhukat
AuthorDiboun, Ilhame
AuthorElrayess, Mohamed A
AuthorButler, Alexandra E
AuthorAtkin, Stephen L
Available date2021-03-09T07:51:21Z
Publication Date2021-03-01
Publication NameScientific Reports
Identifierhttp://dx.doi.org/10.1038/s41598-021-84586-y
CitationMoin, A.S.M., Sathyapalan, T., Diboun, I. et al. Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome. Sci Rep 11, 5320 (2021). https://doi.org/10.1038/s41598-021-84586-y
URIhttp://hdl.handle.net/10576/17878
AbstractPolycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulation pathway protein levels in PCOS (n = 146) and control (n = 97) women recruited to a PCOS biobank. Circulating levels of a panel of 18 clotting pathway proteins were determined by Slow Off-rate Modified Aptamer-scan plasma protein measurement. Cohorts were age matched, though PCOS had elevated body mass index (p < 0.001), insulin (p < 0.001) and C-reactive protein (CRP) (p < 0.0001). Eight pro-coagulation proteins were elevated in PCOS: plasminogen activator inhibitor-1 (p < 0.0001), fibrinogen (p < 0.01), fibrinogen gamma chain (p < 0.0001), fibronectin (p < 0.01), von Willebrand factor (p < 0.05), D-dimer (p < 0.0001), P-selectin (p < 0.05), and plasma kallikrein (p < 0.001). However, two anticoagulant proteins, vitamin K-dependent protein-S (p < 0.0001) and heparin cofactor-II (p < 0.001) were elevated and prothrombin was decreased (p < 0.05). CRP, as a marker of inflammation, and insulin resistance (HOMA-IR) correlated with 11 and 6 of the clotting proteins, respectively (p < 0.05). When matched for BMI < 25 (16 PCOS, 53 controls) HOMA-IR remained elevated (p < 0.05) and heparin cofactor-II was increased (p < 0.05). In a multivariate analysis accounting for inflammation, insulin resistance and BMI, there was no correlation of PCOS with any of the coagulation proteins. The hypercoagulable state in PCOS is not intrinsic to the disease as it can be fully accounted for by BMI, inflammation and insulin resistance.
Languageen
PublisherNature Research
SubjectEndocrine system and metabolic diseases
Endocrinology
Obesity
Pre-diabetes
PCOS
hypercoagulation
BMI
TitleMetabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.
TypeArticle
Issue Number1
Volume Number11
ESSN2045-2322
dc.accessType Open Access


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