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Authoribrahim, wisam nabeel
AuthorYounes, Nadin
AuthorShi, Zumin
AuthorAbu-Madi, Marawan Abdelhamid
Available date2021-04-01T05:32:34Z
Publication Date2021-03-31
Publication NameFrontiers in Endocrinology
Identifierhttp://dx.doi.org/10.3389/fendo.2021.653685
CitationIbrahim WN, Younes N, Shi Z and Abu-Madi MA (2021) Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris. Front. Endocrinol. 12:653685. doi: 10.3389/fendo.2021.653685
URIhttp://hdl.handle.net/10576/18068
AbstractBackground: Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental studies couldn’t draw a clear conclusion on the relation between SUA and bone health. We aim to investigate the association between SUA and bone mineral density (BMD) at different skeletal sites among healthy Qataris. Methodology: A cross-sectional analysis including total-body and site-specific bone mineral density scores and other serological markers of 2981 healthy Qatari adults (36.4 ± 11.1 years) from the Qatar biobank database was conducted. The study participants were divided into quartiles based on the level of SUA, and the BMD was measured using dual-energy X-ray absorptiometry (DXA). Multiple regression analyses were applied to investigate the association between SUA and BMD adjusting for multiple confounding factors. Results: High levels of SUA were significantly associated with the increased bone mineral density of the total body and at site-specific skeletal locations after adjusting for age and gender (p-value < 0.001). Further adjustment for body mass index (BMI), smoking, vitamin D, alkaline phosphatase, and estimated glomerular filtration rate (eGFR) levels attenuated the association but the association remained significant for individuals with high SUA levels (p-value ≤ 0.01).The association between SUA and BMD was not significant in non-obese, females, young adults, and smokers. However, no interaction was found between SUA and age, gender, BMI and smoking. Conclusion: Higher SUA levels are associated with a high bone density among healthy Qatari adults. However, such observation demands further investigations to outline the underlying mechanisms.
Languageen
PublisherFrontiers Media
Subjecturic acid
bone mineral density
osteoporosis
Qatar biobank
antioxidant
eGFR
BMI
smoking
TitleSerum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris
TypeArticle
Volume Number12
ESSN1664-2392
dc.accessType Open Access


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