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المؤلفTarim, E. Alperay
المؤلفKarakuzu, Betul
المؤلفOksuz, Cemre
المؤلفSarigil, Oyku
المؤلفKizilkaya, Melike
المؤلفAl-Ruweidi, Mahmoud Khatib A.A.
المؤلفYalcin, Huseyin Cagatay
المؤلفOzcivici, Engin
المؤلفTekin, H. Cumhur
تاريخ الإتاحة2021-04-29T09:50:53Z
تاريخ النشر2021-01-01
اسم المنشورEmergent Materials
المعرّفhttp://dx.doi.org/10.1007/s42247-021-00169-7
الاقتباسTarim, E.A., Karakuzu, B., Oksuz, C. et al. Microfluidic-based virus detection methods for respiratory diseases. emergent mater. 4, 143-168 (2021). https://doi.org/10.1007/s42247-021-00169-7
الرقم المعياري الدولي للكتاب25225731
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103190091&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/18391
الملخصWith the recent SARS-CoV-2 outbreak, the importance of rapid and direct detection of respiratory disease viruses has been well recognized. The detection of these viruses with novel technologies is vital in timely prevention and treatment strategies for epidemics and pandemics. Respiratory viruses can be detected from saliva, swab samples, nasal fluid, and blood, and collected samples can be analyzed by various techniques. Conventional methods for virus detection are based on techniques relying on cell culture, antigen-antibody interactions, and nucleic acids. However, these methods require trained personnel as well as expensive equipment. Microfluidic technologies, on the other hand, are one of the most accurate and specific methods to directly detect respiratory tract viruses. During viral infections, the production of detectable amounts of relevant antibodies takes a few days to weeks, hampering the aim of prevention. Alternatively, nucleic acid–based methods can directly detect the virus-specific RNA or DNA region, even before the immune response. There are numerous methods to detect respiratory viruses, but direct detection techniques have higher specificity and sensitivity than other techniques. This review aims to summarize the methods and technologies developed for microfluidic-based direct detection of viruses that cause respiratory infection using different detection techniques. Microfluidics enables the use of minimal sample volumes and thereby leading to a time, cost, and labor effective operation. Microfluidic-based detection technologies provide affordable, portable, rapid, and sensitive analysis of intact virus or virus genetic material, which is very important in pandemic and epidemic events to control outbreaks with an effective diagnosis.
راعي المشروعQatar National Research Fund
اللغةen
الناشرSpringer
الموضوعBiosensors
COVID-19
Microfluidic
Respiratory disease
Viral pathogen
Virus Detection
العنوانMicrofluidic-based virus detection methods for respiratory diseases
النوعArticle
الصفحات143-168
رقم المجلد4
dc.accessType Open Access


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