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    miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes. 

    Gentile, Adriana-Mariel; Lhamyani, Said; Coín-Aragüez, Leticia; Clemente-Postigo, Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana-Yanina; García-Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez-Silva, Francisco-Javier; Murri, Mora; Tinahones, Francisco J; El Bekay, Rajaa... more authors ... less authors ( Wiley , 2019 , Article)
    This study aimed to analyze the potential association of different microRNA (miRNA) molecules with both type 2 diabetes (T2D) and obesity and determine their target genes. Quantitative PCR was used to analyze the miR-20b, ...
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    Implication of salt stress induces changes in pigment production, antioxidant enzyme activity, and qRT-PCR expression of genes involved in the biosynthetic pathway of Bixa orellana L. 

    Sankari, M; Hridya, H; Sneha, P; Doss, C George Priya; Christopher, J Godwin; Mathew, Jill; Zayed, Hatem; Ramamoorthy, Siva... more authors ... less authors ( Springer Verlag , 2019 , Article)
    The effect of salt stress on pigment synthesis and antioxidant enzyme activity as well as in the genes involved in the biosynthetic pathway of bixin was studied. The 14-day germinated seedlings of Bixa orellana were induced ...
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    The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer. 

    Siveen, Kodappully S; Raza, Afsheen; Ahmed, Eiman I; Khan, Abdul Q; Prabhu, Kirti S; Kuttikrishnan, Shilpa; Mateo, Jericha M; Zayed, Hatem; Rasul, Kakil; Azizi, Fouad; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( MDPI , 2019 , Article)
    Colorectal cancer (CRC) is one of the most common cancers worldwide, with high morbidity and mortality rates. A number of factors including modulation of the tumor microenvironment, high metastatic capability, and resistance ...
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    Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA 

    Tanwar, Himani; Kumar, D Thirumal; Doss, C George Priya; Zayed, Hatem ( Springer US , 2019 , Article)
    Mucopolysaccharidosis (MPS) IIIA, also known as Sanfilippo syndrome type A, is a severe, progressive disease that affects the central nervous system (CNS). MPS IIIA is inherited in an autosomal recessive manner and is ...
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    An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD and Disulfiram. 

    J, Christy Priyadharshini; D, Thirumal Kumar; P, Sneha; R, Siva; W, Charles Emmanuel Jebaraj; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( Wiley , 2019 , Article)
    Alcohol use disorder (AUD) is a multifactorial psychiatric behavior disorder. Disulfiram is the first approved drug by the Food and Drug Administration for alcohol-dependent patients, which targets the ALDH2 enzyme. Several ...
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    Clinical, biochemical, neuroradiological and molecular characterization of Egyptian patients with glutaric acidemia type 1. 

    Zayed, Hatem; El Khayat, Hamed; Tomoum, Hoda; Khalifa, Ola; Siddiq, Ehab; Mohammad, Shaimaa A; Gamal, Radwa; Shi, Zumin; Mosailhy, Ahmed; Zaki, Osama K... more authors ... less authors ( Springer , 2019 , Article)
    Glutaric acidemia type 1 (GA1) is an inherited metabolic autosomal recessive disorder that is caused by a deficiency in glutaryl-CoA dehydrogenase (GCDH). Untreated patients suffer primarily from severe striatal damage. ...
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    Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. 

    Akhtar, Sabah; Achkar, Iman W; Siveen, Kodappully S; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Ahmed, Eiman I; Sahir, Fairooz; Jerobin, Jayakumar; Raza, Afsheen; Merhi, Maysaloun; Elsabah, Hesham M; Taha, Ruba; Omri, Halima El; Zayed, Hatem; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Frontiers Media , 2019 , Article)
    Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ...
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    Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer. 

    Kumar, S Udhaya; Kumar, D Thirumal; R, Siva; Doss, C George Priya; Zayed, Hatem ( Frontiers Media , 2019 , Article)
    Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC. In the present ...
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    Genetic polymorphisms associated with type 2 diabetes in the Arab world: A systematic review and meta-analysis. 

    Abuhendi, Najat; Qush, Abeer; Naji, Fozieh; Abunada, Hanan; Al Buainain, Reeham; Shi, Zumin; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Article)
    T2DM reach epidemic levels in the Arab countries. In this study, we aimed to perform a systematic review and meta-analysis to underline the susceptibility genetic profile of Arab patients with T2DM that result from SNPs. ...
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    A computational method to characterize the missense mutations in the catalytic domain of GAA protein causing Pompe disease. 

    Thirumal Kumar, D; Umer Niazullah, Maryam; Tasneem, Sadia; Judith, E; Susmita, B; George Priya Doss, C; Selvarajan, E; Zayed, Hatem... more authors ... less authors ( Wiley , 2019 , Article)
    Pompe disease is an autosomal recessive lysosomal storage disease caused by acid α-glucosidase (GAA) deficiency, resulting in intralysosomal accumulation of glycogen, including cardiac, skeletal, and smooth muscle cells. ...
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    • Zayed, Hatem (23)
    • George Priya Doss, C (7) Thirumal Kumar, D (7) n 2009210819 (4) ... View More
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      Article (22) Book chapter (2)
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      Molecular dynamics (4) Arab countries (3) molecular dynamics (3) Molecular docking (2) ... View More
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    • 2019 (24)
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    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

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