• English
    • العربية
  • العربية
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Help
    • Item Submission
    • Publisher policies
    • User guides
    • FAQs
  • About QSpace
    • Vision & Mission
View Item 
  •   Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Research Units
  • Biomedical Research Center
  • Biomedical Research Center Research
  • View Item
  • Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Research Units
  • Biomedical Research Center
  • Biomedical Research Center Research
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Bio-vehicles of cytotoxic drugs for delivery to tumor specific targets for cancer precision therapy

    Thumbnail
    View/Open
    Publisher version (You have accessOpen AccessIcon)
    Publisher version (Check access options)
    Check access options
    review 2021 AL-Mansoori et al.pdf (2.912Mb)
    Date
    2021-12-31
    Author
    Layla, Al-mansoori
    Elsinga, Philip
    Goda, Sayed K.
    Metadata
    Show full item record
    Abstract
    Abnormal structural and molecular changes in malignant tissues were thoroughly investigated and utilized to target tumor cells, hence rescuing normal healthy tissues and lowering the unwanted side effects as non-specific cytotoxicity. Various ligands for cancer cell specific markers have been uncovered and inspected for directional delivery of the anti-cancer drug to the tumor site, in addition to diagnostic applications. Over the past few decades research related to the ligand targeted therapy (LTT) increased tremendously aiming to treat various pathologies, mainly cancers with well exclusive markers. Malignant tumors are known to induce elevated levels of a variety of proteins and peptides known as cancer “markers” as certain antigens (e.g., Prostate specific membrane antigen “PSMA”, carcinoembryonic antigen “CEA”), receptors (folate receptor, somatostatin receptor), integrins (Integrin αvβ3) and cluster of differentiation molecules (CD13). The choice of an appropriate marker to be targeted and the design of effective ligand-drug conjugate all has to be carefully selected to generate the required therapeutic effect. Moreover, since some tumors express aberrantly high levels of more than one marker, some approaches investigated targeting cancer cells with more than one ligand (dual or multi targeting). We aim in this review to report an update on the cancer-specific receptors and the vehicles to deliver cytotoxic drugs, including recent advancements on nano delivery systems and their implementation in targeted cancer therapy. We will discuss the advantages and limitations facing this approach and possible solutions to mitigate these obstacles. To achieve the said aim a literature search in electronic data bases (PubMed and others) using keywords “Cancer specific receptors, cancer specific antibody, tumor specific peptide carriers, cancer overexpressed proteins, gold nanotechnology and gold nanoparticles in cancer treatment” was carried out.
    URI
    https://www.sciencedirect.com/science/article/pii/S0753332221010441
    DOI/handle
    http://dx.doi.org/10.1016/j.biopha.2021.112260
    http://hdl.handle.net/10576/24634
    Collections
    • Biomedical Research Center Research [‎785‎ items ]

    entitlement

    Related items

    Showing items related by title, author, creator and subject.

    • Thumbnail

      Assessment of lung cancer risk factors and mortality in Qatar: A case series study 

      Abdel-Salam, A.-S.G.; Mollazehi, M.; Bandyopadhyay, D.; Malki, A.M.; Shi, Z.; Zayed, H.... more authors ... less authors ( Blackwell Publishing Ltd , 2021 , Article)
      Background: The global burden of cancer has exponentially increased over the last few years. In 2018 alone, approximately more than half of the 18.1 million individuals who had cancer succumbed to it. Lung cancer cases and ...
    • Thumbnail

      The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019 

      Da Cunha, Amanda Ramos; Compton, Kelly; Xu, Rixing; Mishra, Rashmi; Drangsholt, Mark Thomas; Antunes, Jose Leopoldo Ferreira; Kerr, Alexander R.; Acheson, Alistair R.; Lu, Dan; Wallace, Lindsey E.; Kocarnik, Jonathan M.; Fu, Weijia; Dean, Frances E.; Pennini, Alyssa; Henrikson, Hannah Jacqueline; Alam, Tahiya; Ababneh, Emad; Abd-Elsalam, Sherief; Abdoun, Meriem; Abidi, Hassan; Abubaker Ali, Hiwa; Abu-Gharbieh, Eman; Adane, Tigist Demssew; Addo, Isaac Yeboah; Ahmad, Aqeel; Ahmad, Sajjad; Ahmed Rashid, Tarik; Akonde, Maxwell; Al Hamad, Hanadi; Alahdab, Fares; Alimohamadi, Yousef; Alipour, Vahid; Al-Maweri, Sadeq Ali; Alsharif, Ubai; Ansari-Moghaddam, Alireza; Anwar, Sumadi Lukman; Anyasodor, Anayochukwu Edward; Arabloo, Jalal; Aravkin, Aleksandr Y.; Aruleba, Raphael Taiwo; Asaad, Malke; Ashraf, Tahira; Athari, Seyyed Shamsadin; Attia, Sameh; Azadnajafabad, Sina; Azangou-Khyavy, Mohammadreza; Badar, Muhammad; Baghcheghi, Nayereh; Banach, Maciej; Bardhan, Mainak; Barqawi, Hiba Jawdat; Bashir, Nasir Z.; Bashiri, Azadeh; Benzian, Habib; Bernabe, Eduardo; Bhagat, Devidas S.; Bhojaraja, Vijayalakshmi S.; Bjørge, Tone; Bouaoud, Souad; Braithwaite, Dejana; Briko, Nikolay Ivanovich; Calina, Daniela; Carreras, Giulia; Chakraborty, Promit Ananyo; Chattu, Vijay Kumar; Chaurasia, Akhilanand; Chen, Meng Xuan; Cho, William C. S.; Chu, Dinh-Toi; Chukwu, Isaac Sunday; Chung, Eunice; Cruz-Martins, Natália; Dadras, Omid; Dai, Xiaochen; Dandona, Lalit; Dandona, Rakhi; Daneshpajouhnejad, Parnaz; Darvishi Cheshmeh Soltani, Reza; Darwesh, Aso Mohammad; Debela, Sisay Abebe; Derbew Molla, Meseret; Dessalegn, Fikadu Nugusu; Dianati-Nasab, Mostafa; Digesa, Lankamo Ena; Dixit, Shilpi Gupta; Dixit, Abhinav; Djalalinia, Shirin; El Sayed, Iman; El Tantawi, Maha; Enyew, Daniel Berhanie; Erku, Daniel Asfaw; Ezzeddini, Rana; Fagbamigbe, Adeniyi Francis; Falzone, Luca; Fetensa, Getahun; Fukumoto, Takeshi; Gaewkhiew, Piyada; Gallus, Silvano; Gebrehiwot, Mesfin; Ghashghaee, Ahmad; Gill, Paramjit Singh; Golechha, Mahaveer; Goleij, Pouya; Gomez, Ricardo Santiago; Gorini, Giuseppe; Guimaraes,; re Luiz Sena; Gupta, Bhawna; Gupta, Sapna; Gupta, Veer Bala; Gupta, Vivek Kumar; Haj-Mirzaian, Arvin; Halboub, Esam S.; Halwani, Rabih; Hanif, Asif; Hariyani, Ninuk; Harorani, Mehdi; Hasani, Hamidreza; Hassan, Abbas M.; Hassanipour, Soheil; Hassen, Mohammed Bheser; Hay, Simon I.; Hayat, Khezar; Herrera-Serna, Brenda Yuliana; Holla, Ramesh; Horita, Nobuyuki; Hosseinzadeh, Mehdi; Hussain, Salman; Ilesanmi, Olayinka Stephen; Ilic, Irena M.; Ilic, Milena D.; Isola, Gaetano; Jaiswal, Abhishek; Jani, Chinmay T.; Javaheri, Tahereh; Jayarajah, Umesh; Jayaram, Shubha; Joseph, Nitin; Kadashetti, Vidya; Kandaswamy, Eswar; Karanth, Shama D.; Karaye, Ibraheem M.; Kauppila, Joonas H.; Kaur, Harkiran; Keykhaei, Mohammad; Khader, Yousef Saleh; Khajuria, Himanshu; Khanali, Javad; Khatib, Mahalaqua Nazli; Khayat Kashani, Hamid Reza; Khazeei Tabari, Mohammad Amin; Kim, Min Seo; Kompani, Farzad; Koohestani, Hamid Reza; Kumar, G. Anil; Kurmi, Om P.; La Vecchia, Carlo; Lal, Dharmesh Kumar; Landires, Iván; Lasrado, Savita; Ledda, Caterina; Lee, Yo Han; Libra, Massimo; Lim, Stephen S.; Listl, Stefan; Lopukhov, Platon D.; Mafi, Ahmad R.; Mahumud, Rashidul Alam; Malik, Ahmad Azam; Mathur, Manu Raj; Maulud, Sazan Qadir; Meena, Jitendra Kumar; Mehrabi Nasab, Entezar; Mestrovic, Tomislav; Mirfakhraie, Reza; Misganaw, Awoke; Misra, Sanjeev; Mithra, Prasanna; Mohammad, Yousef; Mohammadi, Mokhtar; Mohammadi, Esmaeil; Mokdad, Ali H.; Moni, Mohammad Ali; Moraga, Paula; Morrison, Shane Douglas; Mozaffari, Hamid Reza; Mubarik, Sumaira; Murray, Christopher J. L.; Nair, Tapas Sadasivan; Narasimha Swamy, Sreenivas; Narayana, Aparna Ichalangod; Nassereldine, Hasan; Natto, Zuhair S.; Nayak, Biswa Prakash; Negru, Serban Mircea; Nggada, Haruna Asura; Nouraei, Hasti; Nuñez-Samudio, Virginia; Oancea, Bogdan; Olagunju,; rew T.; Omar Bali, Ahmed; Padron-Monedero, Alicia; Padubidri, Jagadish Rao; Pandey, Anamika; Pardhan, Shahina; Patel, Jay; Pezzani, Raffaele; Piracha, Zahra Zahid; Rabiee, Navid; Radhakrishnan, Venkatraman; Radhakrishnan, Raghu Anekal; Rahmani, Amir Masoud; Rahmanian, Vahid; Rao, Chythra R.; Rao, Sowmya J.; Rath, Goura Kishor; Rawaf, David Laith; Rawaf, Salman; Rawassizadeh, Reza; Razeghinia, Mohammad Sadegh; Rezaei, Nazila; Rezaei, Negar; Rezaei, Nima; Rezapour, Aziz; Riad, Abanoub; Roberts, Thomas J.; Romero-RRodríguez, Esperanza; Roshandel, Gholamreza; Manjula, S.; Chandan, S.N.; Saddik, Basema; Saeb, Mohammad Reza; Saeed, Umar; Safaei, Mohsen; Sahebazzamani, Maryam; Sahebkar, Amirhossein; Salek Farrokhi, Amir; Samy, Abdallah M.; Santric-Milicevic, Milena M.; Sathian, Brijesh; Satpathy, Maheswar; Šekerija, Mario; Senthilkumaran, Subramanian; Seylani, Allen; Shafaat, Omid; Shahsavari, Hamid R.; Shamsoddin, Erfan; Sharew, Mequannent Melaku; Sharifi-Rad, Javad; Shetty, Jeevan K.; Shivakumar, K.M.; Shobeiri, Parnian; Shorofi, Seyed Afshin; Shrestha, Sunil; Siddappa Malleshappa, Sudeep K.; Singh, Paramdeep; Singh, Jasvinder A.; Singh, Garima; Sinha, Dhirendra Narain; Solomon, Yonatan; Suleman, Muhammad; Suliankatchi Abdulkader, Rizwan; Taheri Abkenar, Yasaman; Talaat, Iman M.; Tan, Ker-Kan; Tbakhi, Abdelghani; Thiyagarajan, Arulmani; Tiyuri, Amir; Tovani-Palone, Marcos Roberto; Unnikrishnan, Bhaskaran; Vo, Bay; Volovat, Simona Ruxandra; Wang, Cong; Westerman, Ronny; Wickramasinghe, Nuwan Darshana; Xiao, Hong; Yu, Chuanhua; Yuce, Deniz; Yunusa, Ismaeel; Zadnik, Vesna; Zare, Iman; Zhang, Zhi-Jiang; Zoladl, Mohammad; Force, Lisa M.; Hugo, Fernando N.... more authors ... less authors ( American Medical Association , 2023 , Article)
      Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy ...
    • Thumbnail

      Health Pulse : World Cancer Day 

      ( Qatar University Health , 2023 , Poster)

    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of Digital Hub
      Communities & Collections Publication Date Author Title Subject Type Language Publisher
    This Collection
      Publication Date Author Title Subject Type Language Publisher

    My Account

    Login

    Statistics

    View Usage Statistics

    About QSpace

    Vision & Mission

    Help

    Item Submission Publisher policiesUser guides FAQs

    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Video