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    A Comparative Study of High-intensity Rosuvastatin Versus Atorvastatin Therapy Post-acute Coronary Syndrome Using Real-world Data

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    A Comparative Study of High-intensity Rosuvastatin Versus Atorvastatin Therapy Post-acute Coronary Syndrome Using Real-world Data.pdf (147.5Kb)
    Date
    2021-08
    Author
    Rahhal, Alaa
    Khir, Fadi
    Orabi, Bassant
    Chbib, Salma
    Al-Khalaila, Osama
    Salah Abdelghani, Mohamed
    Osman, Omnia
    Azzam Ashour, Amr
    Al-Awad, Mohammad
    Mahfouz, Ahmed
    Awaisu, Ahmed
    Hussien Aljundi, Amer
    Alahmad, Yaser
    Alyafei, Sumaya
    Rahman Arabi, Abdul
    ...show more authors ...show less authors
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    Abstract
    A high-intensity statin is recommended for the secondary prevention of cardiovascular diseases (CVD). However, real-world evidence of the effectiveness of rosuvastatin following acute coronary syndrome (ACS) is scarce. This retrospective cohort study included patients diagnosed with ACS to compare between the 2 high-intensity statin therapies (rosuvastatin vs atorvastatin) in terms of a primary composite outcome of CVD-associated death, non-fatal ACS, and non-fatal stroke at 1 month and 12 months post discharge. The primary effectiveness outcome did not differ between the 2 groups at 1 month (1.3% vs 1%; aHR = 1.64, 95% CI 0.55-4.94, P= 0.379) and at 12 months (4.8% vs 3.5%; aHR = 1.48, 95% CI 0.82-2.67, P= 0.199). Similarly, the 2 groups had comparable safety outcomes. In conclusion, the use of high-intensity rosuvastatin compared to high-intensity atorvastatin therapy in patients with ACS had resulted in comparable cardiovascular effectiveness and safety outcomes.
    DOI/handle
    http://dx.doi.org/10.1016/j.cpcardiol.2021.100956
    http://hdl.handle.net/10576/24710
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