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المؤلفTripathi, Avantika
المؤلفKashyap, Anjali
المؤلفTripathi, Greesham
المؤلفYadav, Joni
المؤلفBibban, Rakhi
المؤلفAggarwal, Nikita
المؤلفThakur, Kulbhushan
المؤلفChhokar, Arun
المؤلفJadli, Mohit
المؤلفSah, Ashok Kumar
المؤلفVerma, Yeshvandra
المؤلفZayed, Hatem
المؤلفHusain, Amjad
المؤلفBharti, Alok Chandra
المؤلفKashyap, Manoj Kumar
تاريخ الإتاحة2021-11-18T11:38:58Z
تاريخ النشر2021-11-01
اسم المنشورNational Library of Medicine
المعرّفhttp://dx.doi.org/10.1186/s40364-021-00280-1
الاقتباسTripathi A, Kashyap A, Tripathi G, Yadav J, Bibban R, Aggarwal N, Thakur K, Chhokar A, Jadli M, Sah AK, Verma Y, Zayed H, Husain A, Bharti AC, Kashyap MK. Tumor reversion: a dream or a reality. Biomark Res. 2021 May 6;9(1):31. doi: 10.1186/s40364-021-00280-1. PMID: 33958005; PMCID: PMC8101112.
معرّف المصادر الموحدhttp://hdl.handle.net/10576/25009
الملخصReversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative RNA splicing, post-transcriptional, post-translational modifications, availability of proteomics, genomics editing tools, and chemical biology approaches gave hope to manipulation of cancer cells reversion to a normal cell phenotype as evidences are subtle but definitive. Regardless of the advancement, there is a long way to go, as customized techniques are required to be fine-tuned with precision to attain more insights into tumor reversion. Tumor regression models using available genome-editing methods, followed by in vitro and in vivo proteomics profiling techniques show early evidence. This review summarizes tumor reversion developments, present issues, and unaddressed challenges that remained in the uncharted territory to modulate cellular machinery for tumor reversion towards therapeutic purposes successfully. Ongoing research reaffirms the potential promises of understanding the mechanism of tumor reversion and required refinement that is warranted in vitro and in vivo models of tumor reversion, and the potential translation of these into cancer therapy. Furthermore, therapeutic compounds were reported to induce phenotypic changes in cancer cells into normal cells, which will contribute in understanding the mechanism of tumor reversion. Altogether, the efforts collectively suggest that tumor reversion will likely reveal a new wave of therapeutic discoveries that will significantly impact clinical practice in cancer therapy.
اللغةen
الناشرPubmed
الموضوعPTMs
Phenotype reversion
Revertant
SIAH1
TCTP1
Tumor reversion
العنوانTumor reversion: a dream or a reality.
النوعArticle
رقم المجلد9
dc.accessType Open Access


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