Show simple item record

AuthorTripathi, Avantika
AuthorKashyap, Anjali
AuthorTripathi, Greesham
AuthorYadav, Joni
AuthorBibban, Rakhi
AuthorAggarwal, Nikita
AuthorThakur, Kulbhushan
AuthorChhokar, Arun
AuthorJadli, Mohit
AuthorSah, Ashok Kumar
AuthorVerma, Yeshvandra
AuthorZayed, Hatem
AuthorHusain, Amjad
AuthorBharti, Alok Chandra
AuthorKashyap, Manoj Kumar
Available date2021-11-18T11:38:58Z
Publication Date2021-11-01
Publication NameNational Library of Medicine
Identifierhttp://dx.doi.org/10.1186/s40364-021-00280-1
CitationTripathi A, Kashyap A, Tripathi G, Yadav J, Bibban R, Aggarwal N, Thakur K, Chhokar A, Jadli M, Sah AK, Verma Y, Zayed H, Husain A, Bharti AC, Kashyap MK. Tumor reversion: a dream or a reality. Biomark Res. 2021 May 6;9(1):31. doi: 10.1186/s40364-021-00280-1. PMID: 33958005; PMCID: PMC8101112.
URIhttp://hdl.handle.net/10576/25009
AbstractReversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative RNA splicing, post-transcriptional, post-translational modifications, availability of proteomics, genomics editing tools, and chemical biology approaches gave hope to manipulation of cancer cells reversion to a normal cell phenotype as evidences are subtle but definitive. Regardless of the advancement, there is a long way to go, as customized techniques are required to be fine-tuned with precision to attain more insights into tumor reversion. Tumor regression models using available genome-editing methods, followed by in vitro and in vivo proteomics profiling techniques show early evidence. This review summarizes tumor reversion developments, present issues, and unaddressed challenges that remained in the uncharted territory to modulate cellular machinery for tumor reversion towards therapeutic purposes successfully. Ongoing research reaffirms the potential promises of understanding the mechanism of tumor reversion and required refinement that is warranted in vitro and in vivo models of tumor reversion, and the potential translation of these into cancer therapy. Furthermore, therapeutic compounds were reported to induce phenotypic changes in cancer cells into normal cells, which will contribute in understanding the mechanism of tumor reversion. Altogether, the efforts collectively suggest that tumor reversion will likely reveal a new wave of therapeutic discoveries that will significantly impact clinical practice in cancer therapy.
Languageen
PublisherPubmed
SubjectPTMs
Phenotype reversion
Revertant
SIAH1
TCTP1
Tumor reversion
TitleTumor reversion: a dream or a reality.
TypeArticle
Volume Number9
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record