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AuthorAl Khatib, Hebah A.
AuthorMathew, Shilu
AuthorSmatti, Maria K.
AuthorEltai, Nahla O.
AuthorPathan, Sameer A.
AuthorAl Thani, Asmaa A.
AuthorCoyle, Peter V.
AuthorAl Maslamani, Muna A.
AuthorYassine, Hadi M.
Available date2021-11-29T11:32:19Z
Publication Date2021-06-01
Publication NamePathogens
Identifierhttp://dx.doi.org/10.3390/pathogens10060761
CitationAl Khatib, H.A.; Mathew, S.; Smatti, M.K.; Eltai, N.O.; Pathan, S.A.; Al Thani, A.A.; Coyle, P.V.; Al Maslamani, M.A.; Yassine, H.M. Profiling of Intestinal Microbiota in Patients Infected with Respiratory Influenza A and B Viruses. Pathogens 2021, 10, 761. https://doi.org/ 10.3390/pathogens10060761
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108995451&origin=inward
URIhttp://hdl.handle.net/10576/25193
AbstractLittle is known about the association between respiratory viral infections and their impact on intestinal microbiota. Here, we compared the effect of influenza types, A and B, and influenza shedding in patients’ stools on the gut microbiota diversity and composition. Deep sequencing analysis was performed for the V4 region of the 16S rRNA gene. Fecal samples were collected from 38 adults with active respiratory influenza infection and 11 age-matched healthy controls. Influenza infection resulted in variations in intestinal bacterial community composition rather than in overall diversity. Overall, infected patients experienced an increased abundance of Bacteroidetes and a corresponding decrease in Firmicutes. Differential abundance testing illustrated that differences in gut microbiota composition were influenza type-dependent, identifying ten differentially abun-dant operational taxonomic units (OTUs) between influenza A-and influenza B-infected patients. Notably, virus shedding in fecal samples of some patients had significantly reduced gut bacterial diversity (p = 0.023). Further taxonomic analysis revealed that the abundance of Bacteroides fragilis was significantly higher among shedders compared to non-shedders (p = 0.037). These results pro-vide fundamental evidence of the direct effect of influenza infection on gut microbiota diversity, as reported in patients shedding the virus.
Languageen
PublisherMDPI
SubjectDiversity
Influenza
Intestine microbiome
Virus shedding
TitleProfiling of intestinal microbiota in patients infected with respiratory influenza a and b viruses
TypeArticle
Issue Number6
Volume Number10
dc.accessType Open Access


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