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AuthorHaidar, Muhammad Ali
AuthorShakkour, Zaynab
AuthorReslan, Mohammad Amine
AuthorAl-Haj, Nadine
AuthorChamoun, Perla
AuthorHabashy, Karl
AuthorKaafarani, Hasan
AuthorShahjouei, Shima
AuthorFarran, Sarah H
AuthorShaito, Abdullah
AuthorSaba, Esber S
AuthorBadran, Bassam
AuthorSabra, Mirna
AuthorKobeissy, Firas
AuthorBizri, Maya
Available date2021-11-29T11:52:26Z
Publication Date2022-06-01
Publication NameNeural Regeneration Research
Identifierhttp://dx.doi.org/10.4103/1673-5374.327323
CitationHaidar MA, Shakkour Z, Reslan MA, Al-Haj N, Chamoun P, Habashy K, Kaafarani H, Shahjouei S, Farran SH, Shaito A, Saba ES, Badran B, Sabra M, Kobeissy F, Bizri M (2022) SARS-CoV-2 involvement in central nervous system tissue damage. Neural Regen Res 17(6):1228-1239.
URIhttp://hdl.handle.net/10576/25196
AbstractAs the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.
Languageen
PublisherWolters Kluwer
SubjectCNS infection
COVID-19
autoantibodies
coagulopathy
encephalitis
neuroinflammation
renin-angiotensin system
viral encephalopathy
TitleSARS-CoV-2 involvement in central nervous system tissue damage
TypeArticle Review
Pagination1228-1239
Issue Number6
Volume Number17
dc.accessType Open Access


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