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AuthorHassani, Abdelkader
AuthorHussain, Siti Aslina
AuthorAl-Qubaisi, Mothanna Sadiq
AuthorBelfar, Mohamed Lakhder
AuthorBelkhalfa, Hakim
AuthorEnezei, Hamid Hammad
AuthorZentou, Hamid
AuthorIbrahim, Wisam Nabeel
AuthorDoolaanea, Abd Almonem
Available date2021-12-23T09:04:02Z
Publication Date2022-01-01
Publication NameBiocell
Identifierhttp://dx.doi.org/10.32604/biocell.2022.016848
CitationHASSANI, A., HUSSAIN, S. A., AL-QUBAISI, M. S., BELFAR, M. L., BELKHALFA, H. et al. (2022). Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells. BIOCELL, 46(3), 677–687.
ISSN03279545
URIhttp://hdl.handle.net/10576/25607
AbstractThe main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.
Languageen
PublisherTech Science Press
SubjectAntioxidants
Cancer cells
Curcumin
Gum arabic
Nanoparticles
TitleCurcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells
TypeArticle
Pagination677-687
Issue Number3
Volume Number46
ESSN1667-5746
dc.accessType Open Access


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