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المؤلفNehal E., Abdel-Hakem
المؤلفTalaat, Roba M.
المؤلفSamaka, Rehab M.
المؤلفBassyouniy, Iman H.
المؤلفEL-Shahat, Mohamed
المؤلفAlkawareek, Mahmoud Y.
المؤلفAlkilany, Alaaldin M.
تاريخ الإتاحة2022-01-24T08:34:58Z
تاريخ النشر2022-01-31
اسم المنشورJournal of Drug Delivery Science and Technology
المعرّفhttp://dx.doi.org/10.1016/j.jddst.2021.102944
الاقتباسAbdel-Hakem, N. E., Talaat, R. M., Samaka, R. M., Bassyouniy, I. H., Mohamed, E. S., Alkawareek, M. Y., & Alkilany, A. M. (2021). Therapeutic outcomes and biodistribution of gold nanoparticles in collagen-induced arthritis animal model. Journal of Drug Delivery Science and Technology, 102944.
الرقم المعياري الدولي للكتاب17732247
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1773224721006249
معرّف المصادر الموحدhttp://hdl.handle.net/10576/25886
الملخصThe role of gold nanoparticles (AuNPs) in the treatment of autoimmune diseases remains mysterious. Therefore, we investigated the effect of AuNPs on collagen-induced arthritis (CIA) and the impact of particle size on the tissue distribution of AuNPs. CIA model was set up in Wistar rats using bovine collagen type ІІ. CIA rats were then divided into five groups: CIA model (positive control), AuNPs treated- (sphere shape with size: 5, 25, and 75 nm), and methotrexate (MTX)-treated-rats. Untreated rats were run in parallel as normal control. At the end of the experiment, the radiographic assessment was done. Histopathological changes in the joints and vital organs were investigated. Liver- [aspartate transaminase (AST) and alanine transaminase (ALT)] and kidney- (creatinine) functions were measured. The gold bio-accumulation was measured quantitatively with inductively coupled plasma mass spectrometry (ICP-MS). Histopathological results revealed that AuNPs reduced the severity of arthritic symptoms in CIA rats. No histological changes were detected in vital organs. Importantly, AuNPs were deposited in all the examined organs, and the accumulation was size-dependent, with 75 nm demonstrated the least distributed one. Our results revealed that AuNPs decreased both liver and kidney functions as compared to normal controls. In conclusion, our data shed light on the therapeutic efficacy of AuNPs in experimental rheumatoid arthritis compared with a choice size (25 nm). Further investigations to investigate the immunological changes associated with AuNPs are in process.
راعي المشروعThis work was funded by the Science and Technology Development Fund (STDF), Egyptian Academy of Scientific Research and Technology (ASRT), Egypt (Grant No. 22996), and the Jordan Scientific Research Support Fund (SRSF), Jordan (Grant no. Egy-Jor/March 1, 2015).
اللغةen
الناشرElsevier
الموضوعRheumatoid arthritis
Collagen-induced arthritis
Gold nanoparticles
Histopathology
Gold deposition
العنوانTherapeutic outcomes and biodistribution of gold nanoparticles in collagen-induced arthritis animal model
النوعOther
رقم المجلد67


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