Show simple item record

AuthorMoltrasio, Chiara
AuthorTricarico, Paola Maura
AuthorGenovese, Giovanni
AuthorGratton, Rossella
AuthorMarzano, Angelo V.
AuthorCrovella, Sergio
Available date2022-01-25T05:46:37Z
Publication Date2021-05-01
Publication NameJournal of Dermatology
Identifierhttp://dx.doi.org/10.1111/1346-8138.15797
CitationMoltrasio, C., Tricarico, P.M., Genovese, G., Gratton, R., Marzano, A.V. and Crovella, S. (2021), 25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa. J. Dermatol., 48: 715-717. https://doi.org/10.1111/1346-8138.15797
ISSN03852407
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101597182&origin=inward
URIhttp://hdl.handle.net/10576/25908
AbstractVitamin D exerts functions in skin physiology by modulating keratinocyte proliferation and different immunoregulatory processes.1 In several dermatoses, vitamin D correlates to disease severity and is significantly lower if compared to healthy subjects.2 Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful suppurating lesions mainly localized in the folds.3 Kelly et al.4 conducted the first study assessing vitamin D status in HS, concluding that 75% of patients had vitamin D levels of less than 50 nmol/L compared to 40% of the general population. Subsequently, Guillet et al.5 described an association between vitamin D deficiency and HS severity, also reporting a significant decrease of the inflammatory nodules in patients supplemented with vitamin D. The same authors found a correlation between the response to HS therapies and increased vitamin D levels upon supplementation. Likewise, Fabbrocini et al.6 found an inverse correlation between vitamin D levels and disease severity in refractory HS and reported the improvement of clinical responsiveness to therapies as directly proportional to the increase of vitamin D level following supplementation. A recent study demonstrated through whole exome sequencing the role of vitamin D metabolism dysfunction in syndromic HS pathogenesis, molecularly reinforcing the clinical observations of the above-mentioned studies.7
Languageen
PublisherWiley
Subject25-Hydroxyvitamin D serum
serum C
D serum
Title25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa
TypeOther
Pagination715-717
Issue Number5
Volume Number48
ESSN1346-8138
dc.accessType Full Text


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record