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المؤلفAmador, Vinícius Costa
المؤلفSantos-Silva, Carlos André Dos
المؤلفVilela, Lívia Maria Batista
المؤلفOliveira-Lima, Marx
المؤلفde Santana Rêgo, Mireli
المؤلفRoldan-Filho, Ricardo Salas
المؤلفde Oliveira-Silva, Roberta Lane
المؤلفLemos, Ayug Bezerra
المؤلفde Oliveira, Wilson Dias
المؤلفFerreira-Neto, José Ribamar Costa
المؤلفCrovella, Sérgio
المؤلفBenko-Iseppon, Ana Maria
تاريخ الإتاحة2022-01-25T08:34:19Z
تاريخ النشر2021-11-01
اسم المنشورAntibiotics
المعرّفhttp://dx.doi.org/10.3390/antibiotics10111281
الاقتباسAmador, V.C.; Santos-Silva, C.A.d.; Vilela, L.M.B.; Oliveira-Lima, M.; de Santana Rêgo, M.; Roldan-Filho, R.S.; Oliveira-Silva, R.L.d.; Lemos, A.B.; de Oliveira, W.D.; Ferreira-Neto, J.R.C.; Crovella, S.; Benko-Iseppon, A.M. Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity. Antibiotics 2021, 10, 1281. https://doi.org/10.3390/antibiotics10111281
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85119184504&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/25927
الملخصLipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP research, addressing not only their structural, evolutionary and further predicted functional aspects. Traditionally, LTPs have been identified by their direct isolation by biochemical techniques, whereas omics data and bioinformatics deserve special attention for their potential to bring new insights. In this context, new possible functions have been identified revealing that LTPs are actually multipurpose, with many additional predicted roles. Despite some challenges due to the toxicity and allergenicity of LTPs, a systematic review and search in patent databases, indicate promising perspectives for the biotechnological use of LTPs in human health and also plant defense.
راعي المشروعThe research received financial support of FACEPE (Fundação de Amparo à Pesquisa do Estado de Pernambuco, Brazil) CNPq (Conselho Nacional de Desenvolvimento Científico Tecnológico, no. 313581/2020-7, 442019/2019-0, and 433931/2018-3) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, no. 88881.507105/2020-01) throught research funding and fellowships grants.
اللغةen
الناشرMDPI
الموضوعBioinformatics
Cationic peptides
Omics databases
Prediction directed analysis
العنوانLipid transfer proteins (Ltps)- structure, diversity and roles beyond antimicrobial activity
النوعArticle Review
رقم العدد11
رقم المجلد10
ESSN2079-6382
dc.accessType Open Access


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