Show simple item record

AuthorAmador, Vinícius Costa
AuthorSantos-Silva, Carlos André Dos
AuthorVilela, Lívia Maria Batista
AuthorOliveira-Lima, Marx
Authorde Santana Rêgo, Mireli
AuthorRoldan-Filho, Ricardo Salas
Authorde Oliveira-Silva, Roberta Lane
AuthorLemos, Ayug Bezerra
Authorde Oliveira, Wilson Dias
AuthorFerreira-Neto, José Ribamar Costa
AuthorCrovella, Sérgio
AuthorBenko-Iseppon, Ana Maria
Available date2022-01-25T08:34:19Z
Publication Date2021-11-01
Publication NameAntibiotics
Identifierhttp://dx.doi.org/10.3390/antibiotics10111281
CitationAmador, V.C.; Santos-Silva, C.A.d.; Vilela, L.M.B.; Oliveira-Lima, M.; de Santana Rêgo, M.; Roldan-Filho, R.S.; Oliveira-Silva, R.L.d.; Lemos, A.B.; de Oliveira, W.D.; Ferreira-Neto, J.R.C.; Crovella, S.; Benko-Iseppon, A.M. Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity. Antibiotics 2021, 10, 1281. https://doi.org/10.3390/antibiotics10111281
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85119184504&origin=inward
URIhttp://hdl.handle.net/10576/25927
AbstractLipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP research, addressing not only their structural, evolutionary and further predicted functional aspects. Traditionally, LTPs have been identified by their direct isolation by biochemical techniques, whereas omics data and bioinformatics deserve special attention for their potential to bring new insights. In this context, new possible functions have been identified revealing that LTPs are actually multipurpose, with many additional predicted roles. Despite some challenges due to the toxicity and allergenicity of LTPs, a systematic review and search in patent databases, indicate promising perspectives for the biotechnological use of LTPs in human health and also plant defense.
SponsorThe research received financial support of FACEPE (Fundação de Amparo à Pesquisa do Estado de Pernambuco, Brazil) CNPq (Conselho Nacional de Desenvolvimento Científico Tecnológico, no. 313581/2020-7, 442019/2019-0, and 433931/2018-3) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, no. 88881.507105/2020-01) throught research funding and fellowships grants.
Languageen
PublisherMDPI
SubjectBioinformatics
Cationic peptides
Omics databases
Prediction directed analysis
TitleLipid transfer proteins (Ltps)- structure, diversity and roles beyond antimicrobial activity
TypeArticle Review
Issue Number11
Volume Number10
ESSN2079-6382
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record