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AuthorMothanna Sadiq, Al-Qubaisi
AuthorAl-Abboodi, Ashwaq Shakir
AuthorAlhassan, Fatah H.
AuthorHussein-Al-Ali, Samer
AuthorFlaifel, Moayad Husein
AuthorEid, Eltayeb E.M.
AuthorAlshwyeh, Hussah Abdullah
AuthorHussein, Mohd Zobir
AuthorAlnasser, Sulaiman Mohammed
AuthorSaeed, Mohammed Ibrahim
AuthorRasedee, Abdullah
AuthorIbrahim, Wisam Nabeel
Available date2022-02-22T05:56:15Z
Publication Date2022-02-07
Publication NameSaudi Pharmaceutical Journal
Identifierhttp://dx.doi.org/10.1016/j.jsps.2022.02.002
CitationAl-Qubaisi, M. S., Al-Abboodi, A. S., Alhassan, F. H., Hussein-Al-Ali, S., Flaifel, M. H., Eid, E. E., ... & Ibrahim, W. N. (2022). Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite. Saudi Pharmaceutical Journal.
ISSN13190164
URIhttps://www.sciencedirect.com/science/article/pii/S1319016422000408
URIhttp://hdl.handle.net/10576/27354
AbstractIn this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of nitric oxide, prostaglandin E2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorporated in the highly thermal stable nanoparticles. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclusion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective anti-inflammatory therapeutic compound.
SponsorThe publication of this article was funded by the Qatar National Library.
Languageen
PublisherElsevier
SubjectNanocomposite
High-pressure homogenizer
Drug release
RAW 264.7 cells
Inflammatory mediators
TitlePreparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite
TypeArticle
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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