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AuthorZupin, Luisa
AuthorGratton, Rossella
AuthorMilani, Margherita
AuthorClemente, Libera
AuthorFontana, Francesco
AuthorRuscio, Maurizio
AuthorCrovella, Sergio
Available date2022-02-22T07:34:16Z
Publication Date2022-02-06
Publication NameJournal of Biophotonics
Identifierhttp://dx.doi.org/10.1002/jbio.202100375
CitationZupin, L., Gratton, R., Milani, M., Clemente, L., Fontana, F., Ruscio, M., Crovella, S., J. Biophotonics 2022, e202100375. https://doi.org/10.1002/jbio.202100375
ISSN1864-063X
URIhttp://hdl.handle.net/10576/27375
AbstractBlue light has been already reported as able to counteract different types of microorganisms including Gram-positive and Gram-negative bacteria, fungi and viruses, especially the enveloped ones. It has been reported that both blue and visible light can efficiently impact SARS-CoV-2 by affecting its ability to replicate in in vitro cellular models of infection. In this study, blue light at 450, 454 and 470 nm was tested on SARS-CoV-2 to evaluate the residual viral infectious potential on Vero E6, Caco-2 and Calu-3 cells, after the irradiation of viral particles. Following 12' of irradiation at 40 mW/cm , a drastic block of viral amplification was observed. Indeed, at 7 days post-irradiation/infection the viral load was the same as the one measured 1 day post-irradiation/infection, and cellular viability was maintained showing similar levels to the noninfected control cells. Taken together our results indicate that blue LED lamps can be considered as a cheap and convenient tool for SARS-CoV-2 disinfection.
SponsorIRCCS Burlo Garofolo/Italian Ministry of Health, Grant/Award Numbers: RC 15/2017, 03/2020, 47/2020
Languageen
PublisherWiley
SubjectSARS-CoV-2
antiviral
blue LED
disinfection
photobiomodulation therapy
TitleDirect inactivation of SARS-CoV-2 by low level blue photobiomodulation LED at 470, 454 and 450 nm.
TypeArticle
ESSN1864-0648
dc.accessType Open Access


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